Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties
Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/42565/1/FULL%20TEXT.pdf |
| _version_ | 1825716059394539520 |
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| author | Jiayu He Yuandong Liu Xiaofeng Zeng Yan Tong Run Liu Kan Wang Xiangdong Shangguan Guanzhou Qiu Coswald Stephen Sipaut @ Mohd Nasri |
| author_facet | Jiayu He Yuandong Liu Xiaofeng Zeng Yan Tong Run Liu Kan Wang Xiangdong Shangguan Guanzhou Qiu Coswald Stephen Sipaut @ Mohd Nasri |
| author_sort | Jiayu He |
| collection | UMS |
| description | Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants. |
| first_indexed | 2025-03-05T01:35:14Z |
| format | Article |
| id | ums.eprints-42565 |
| institution | Universiti Malaysia Sabah |
| language | English |
| last_indexed | 2025-03-05T01:35:14Z |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | ums.eprints-425652025-01-13T08:18:29Z https://eprints.ums.edu.my/id/eprint/42565/ Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties Jiayu He Yuandong Liu Xiaofeng Zeng Yan Tong Run Liu Kan Wang Xiangdong Shangguan Guanzhou Qiu Coswald Stephen Sipaut @ Mohd Nasri RA1-1270 Public aspects of medicine TA1-2040 Engineering (General). Civil engineering (General) Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants. MDPI 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/42565/1/FULL%20TEXT.pdf Jiayu He and Yuandong Liu and Xiaofeng Zeng and Yan Tong and Run Liu and Kan Wang and Xiangdong Shangguan and Guanzhou Qiu and Coswald Stephen Sipaut @ Mohd Nasri (2023) Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties. Journal of Functional Biomaterials, 14. pp. 1-16. https://doi.org/10.3390/jfb14110552 |
| spellingShingle | RA1-1270 Public aspects of medicine TA1-2040 Engineering (General). Civil engineering (General) Jiayu He Yuandong Liu Xiaofeng Zeng Yan Tong Run Liu Kan Wang Xiangdong Shangguan Guanzhou Qiu Coswald Stephen Sipaut @ Mohd Nasri Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties |
| title | Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties |
| title_full | Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties |
| title_fullStr | Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties |
| title_full_unstemmed | Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties |
| title_short | Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties |
| title_sort | silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties cytocompatibility in vitro and anti bacterial properties |
| topic | RA1-1270 Public aspects of medicine TA1-2040 Engineering (General). Civil engineering (General) |
| url | https://eprints.ums.edu.my/id/eprint/42565/1/FULL%20TEXT.pdf |
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