2-methoxyestradiol TPGS micelles attenuate cyclosporine A-induced nephrotoxicity in rats through inhibition of TGF-β1 and p-ERK1/2 axis

2-methoxyestradiol TPGS micelles attenuate cyclosporine A-induced nephrotoxicity in rats through inhibition of TGF-β1 and p-ERK1/2 axis

The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects. Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it suffers poor bioavailability after oral administration. The purpose of this study was to evaluate the potential of 2ME...

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Bibliographic Details
Main Authors: Al-Rabia, Mohammed W., Alfaleh, Mohamed A., Asfour, Hani Z., Alharbi, Waleed S., El-Moselhy, Mohamed A., Alhakamy, Nabil A., Fahmy, Usama A., Ahmed, Osama A. A., Fahmy, Omar, Rashad, Omar M., Alamoudi, Abdulmohsin J., Abdel-Naim, Ashraf
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2022

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