Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components
Melicope glabra (Blume) T.G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect of M. glabra leaves extract on diabetic rats and identify its bioactive components. The induc-tion of diabetes in Sprague-Dawley rats was done by a combination of h...
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| Format: | Article |
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International Society for Nutraceuticals and Functional Foods
2022
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| author | Quek, Alexandra Tan, Dai Chuan Lim, Pei Cee Kassim, Nur Kartinee Ismail, Amin Shaari, Khozirah Mohd Shuib, Siti Nuraisyah |
| author_facet | Quek, Alexandra Tan, Dai Chuan Lim, Pei Cee Kassim, Nur Kartinee Ismail, Amin Shaari, Khozirah Mohd Shuib, Siti Nuraisyah |
| author_sort | Quek, Alexandra |
| collection | UPM |
| description | Melicope glabra (Blume) T.G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect of M. glabra leaves extract on diabetic rats and identify its bioactive components. The induc-tion of diabetes in Sprague-Dawley rats was done by a combination of high-fat diet and low-dose streptozotocin injection. The M. glabra extracts and standard sitagliptin were orally administered once daily to the diabetic rats for 28 days. The diabetic rats showed drastic weight loss, hyperglycemia, poor glucose tolerance, hyperlipidemia, and disturbances in the liver and kidney functions. However, oral administration of M. glabra extracts to the dia-betic rats significantly lowered the DPP-4 level and increased glucagon-like peptide-1 (GLP-1) level. Scopoletin, pachypodol, and stigmasterol were revealed as the active DPP-4 and α-amylase inhibitors. This study revealed novel findings which suggest the potential of M. glabra as alternative antidiabetic treatment and source of anti-diabetic agents |
| first_indexed | 2024-04-09T03:50:03Z |
| format | Article |
| id | upm.eprints-100288 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-04-09T03:50:03Z |
| publishDate | 2022 |
| publisher | International Society for Nutraceuticals and Functional Foods |
| record_format | dspace |
| spelling | upm.eprints-1002882024-03-18T03:40:02Z http://psasir.upm.edu.my/id/eprint/100288/ Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components Quek, Alexandra Tan, Dai Chuan Lim, Pei Cee Kassim, Nur Kartinee Ismail, Amin Shaari, Khozirah Mohd Shuib, Siti Nuraisyah Melicope glabra (Blume) T.G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect of M. glabra leaves extract on diabetic rats and identify its bioactive components. The induc-tion of diabetes in Sprague-Dawley rats was done by a combination of high-fat diet and low-dose streptozotocin injection. The M. glabra extracts and standard sitagliptin were orally administered once daily to the diabetic rats for 28 days. The diabetic rats showed drastic weight loss, hyperglycemia, poor glucose tolerance, hyperlipidemia, and disturbances in the liver and kidney functions. However, oral administration of M. glabra extracts to the dia-betic rats significantly lowered the DPP-4 level and increased glucagon-like peptide-1 (GLP-1) level. Scopoletin, pachypodol, and stigmasterol were revealed as the active DPP-4 and α-amylase inhibitors. This study revealed novel findings which suggest the potential of M. glabra as alternative antidiabetic treatment and source of anti-diabetic agents International Society for Nutraceuticals and Functional Foods 2022-09-30 Article PeerReviewed Quek, Alexandra and Tan, Dai Chuan and Lim, Pei Cee and Kassim, Nur Kartinee and Ismail, Amin and Shaari, Khozirah and Mohd Shuib, Siti Nuraisyah (2022) Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components. Journal of Food Bioactives, 19. 143 - 153. ISSN 2637-8752; ESSN: 2637-8779 http://www.isnff-jfb.com/index.php/JFB/article/view/297 10.31665/JFB.2022.18320 |
| spellingShingle | Quek, Alexandra Tan, Dai Chuan Lim, Pei Cee Kassim, Nur Kartinee Ismail, Amin Shaari, Khozirah Mohd Shuib, Siti Nuraisyah Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components |
| title | Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components |
| title_full | Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components |
| title_fullStr | Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components |
| title_full_unstemmed | Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components |
| title_short | Antidiabetic effect of Melicope glabra (Blume) T.G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components |
| title_sort | antidiabetic effect of melicope glabra blume t g hartley rutaceae in high fat diet streptozotocin induced diabetic rats and its bioactive components |
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