Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study
Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, u...
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| Format: | Article |
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Elsevier
2022
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| _version_ | 1796983892925743104 |
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| author | Ismail, Norliana Hassan, Noraryana Abd Hamid, Muhammad Hairul Nizam Yusoff, Ummi Nadiah Khamal, Noor Raihan Omar, Mohd Azahadi Xin, Ci Wong Pathmanathan, Mohan Dass Mohd Zin, Shahanizan Muhammad Zin, Faizah Nik Mohamed, Mohamad Haniki Mohd Nor, Norashidah |
| author_facet | Ismail, Norliana Hassan, Noraryana Abd Hamid, Muhammad Hairul Nizam Yusoff, Ummi Nadiah Khamal, Noor Raihan Omar, Mohd Azahadi Xin, Ci Wong Pathmanathan, Mohan Dass Mohd Zin, Shahanizan Muhammad Zin, Faizah Nik Mohamed, Mohamad Haniki Mohd Nor, Norashidah |
| author_sort | Ismail, Norliana |
| collection | UPM |
| description | Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia.
Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status.
Results: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups.
Conclusion: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection. |
| first_indexed | 2024-03-06T11:12:49Z |
| format | Article |
| id | upm.eprints-100428 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:12:49Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-1004282023-12-15T23:13:21Z http://psasir.upm.edu.my/id/eprint/100428/ Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study Ismail, Norliana Hassan, Noraryana Abd Hamid, Muhammad Hairul Nizam Yusoff, Ummi Nadiah Khamal, Noor Raihan Omar, Mohd Azahadi Xin, Ci Wong Pathmanathan, Mohan Dass Mohd Zin, Shahanizan Muhammad Zin, Faizah Nik Mohamed, Mohamad Haniki Mohd Nor, Norashidah Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status. Results: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups. Conclusion: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection. Elsevier 2022-03 Article PeerReviewed Ismail, Norliana and Hassan, Noraryana and Abd Hamid, Muhammad Hairul Nizam and Yusoff, Ummi Nadiah and Khamal, Noor Raihan and Omar, Mohd Azahadi and Xin, Ci Wong and Pathmanathan, Mohan Dass and Mohd Zin, Shahanizan and Muhammad Zin, Faizah and Nik Mohamed, Mohamad Haniki and Mohd Nor, Norashidah (2022) Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study. International Journal of Infectious Diseases, 116. pp. 189-196. ISSN 1201-9712 https://www.sciencedirect.com/science/article/pii/S1201971222000121 10.1016/j.ijid.2022.01.011 |
| spellingShingle | Ismail, Norliana Hassan, Noraryana Abd Hamid, Muhammad Hairul Nizam Yusoff, Ummi Nadiah Khamal, Noor Raihan Omar, Mohd Azahadi Xin, Ci Wong Pathmanathan, Mohan Dass Mohd Zin, Shahanizan Muhammad Zin, Faizah Nik Mohamed, Mohamad Haniki Mohd Nor, Norashidah Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study |
| title | Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study |
| title_full | Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study |
| title_fullStr | Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study |
| title_full_unstemmed | Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study |
| title_short | Association of smoking and severity of COVID-19 infection among 5,889 patients in Malaysia: a multi-center observational study |
| title_sort | association of smoking and severity of covid 19 infection among 5 889 patients in malaysia a multi center observational study |
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