Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor
Abnormality of dopamine (DA), a vital neurotransmitter in the brain’s neuronal pathways, causes several neurological diseases. Rapid and sensitive sensors for DA detection are required for early diagnosis of such disorders. Herein, a carbon quantum dot (CQD)-based refractive index surface plasmon r...
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| Format: | Article |
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MDPI
2022
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| author | Eddin, Faten Bashar Kamal Fen, Yap Wing Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Omar, Nur Alia Sheh Anuar, Muhammad Fahmi Hashim, Hazwani Suhaila Sadrolhosseini, Amir Reza Abdullah, Huda |
| author_facet | Eddin, Faten Bashar Kamal Fen, Yap Wing Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Omar, Nur Alia Sheh Anuar, Muhammad Fahmi Hashim, Hazwani Suhaila Sadrolhosseini, Amir Reza Abdullah, Huda |
| author_sort | Eddin, Faten Bashar Kamal |
| collection | UPM |
| description | Abnormality of dopamine (DA), a vital neurotransmitter in the brain’s neuronal pathways,
causes several neurological diseases. Rapid and sensitive sensors for DA detection are required for early diagnosis of such disorders. Herein, a carbon quantum dot (CQD)-based refractive index surface plasmon resonance (SPR) sensor was designed. The sensor performance was evaluated for various concentrations of DA. Increasing DA levels yielded blue-shifted SPR dips. The experimental findings revealed an excellent sensitivity response of 0.138◦/pM in a linear range from 0.001 to 100 pM and a high binding affinity of 6.234 TM−1. The effects of varied concentrations of DA on the optical characteristics of CQD thin film were further proved theoretically. Increased DA levels decreased the thickness and real part of the refractive index of CQD film, according to fitting results. Furthermore, the observed reduction in surface roughness using AFM demonstrated that DA was bound to the sensor layer. This, in turn, explained the blue shift in SPR reflectance curves. This optical sensor offers great potential as a trustworthy solution for direct measurement due to its simple construction,
high sensitivity, and other sensing features. |
| first_indexed | 2024-03-06T11:14:19Z |
| format | Article |
| id | upm.eprints-100969 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:14:19Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-1009692023-07-13T07:41:37Z http://psasir.upm.edu.my/id/eprint/100969/ Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor Eddin, Faten Bashar Kamal Fen, Yap Wing Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Omar, Nur Alia Sheh Anuar, Muhammad Fahmi Hashim, Hazwani Suhaila Sadrolhosseini, Amir Reza Abdullah, Huda Abnormality of dopamine (DA), a vital neurotransmitter in the brain’s neuronal pathways, causes several neurological diseases. Rapid and sensitive sensors for DA detection are required for early diagnosis of such disorders. Herein, a carbon quantum dot (CQD)-based refractive index surface plasmon resonance (SPR) sensor was designed. The sensor performance was evaluated for various concentrations of DA. Increasing DA levels yielded blue-shifted SPR dips. The experimental findings revealed an excellent sensitivity response of 0.138◦/pM in a linear range from 0.001 to 100 pM and a high binding affinity of 6.234 TM−1. The effects of varied concentrations of DA on the optical characteristics of CQD thin film were further proved theoretically. Increased DA levels decreased the thickness and real part of the refractive index of CQD film, according to fitting results. Furthermore, the observed reduction in surface roughness using AFM demonstrated that DA was bound to the sensor layer. This, in turn, explained the blue shift in SPR reflectance curves. This optical sensor offers great potential as a trustworthy solution for direct measurement due to its simple construction, high sensitivity, and other sensing features. MDPI 2022-05-25 Article PeerReviewed Eddin, Faten Bashar Kamal and Fen, Yap Wing and Muhamad Fauzi, Nurul Illya and Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim and Omar, Nur Alia Sheh and Anuar, Muhammad Fahmi and Hashim, Hazwani Suhaila and Sadrolhosseini, Amir Reza and Abdullah, Huda (2022) Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor. Nanomaterials, 12 (11). art. no. 1799. pp. 1-17. ISSN 2079-4991 https://www.mdpi.com/2079-4991/12/11/1799 10.3390/nano12111799 |
| spellingShingle | Eddin, Faten Bashar Kamal Fen, Yap Wing Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Omar, Nur Alia Sheh Anuar, Muhammad Fahmi Hashim, Hazwani Suhaila Sadrolhosseini, Amir Reza Abdullah, Huda Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
| title | Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
| title_full | Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
| title_fullStr | Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
| title_full_unstemmed | Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
| title_short | Direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
| title_sort | direct and sensitive detection of dopamine using carbon quantum dots based refractive index surface plasmon resonance sensor |
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