Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study
This study aimed to determine the association between hemoglobin (Hb) concentration and Hb change, during early to mid-pregnancy with the risk of gestational diabetes mellitus (GDM). This was a clinic-based retrospective cohort study of 1951 healthy pregnant women (18–45 years old) with a singleton...
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| Format: | Article |
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Cambridge University Press
2022
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| _version_ | 1796984010657759232 |
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| author | Heng, Yaw Yong Mohd Shariff, Zalilah Mohd Yusof, Barakatun Nisak Rejali, Zulida Yee, Yvonne Siang Tee Bindels, Jacques van der Beek, Eline M. |
| author_facet | Heng, Yaw Yong Mohd Shariff, Zalilah Mohd Yusof, Barakatun Nisak Rejali, Zulida Yee, Yvonne Siang Tee Bindels, Jacques van der Beek, Eline M. |
| author_sort | Heng, Yaw Yong |
| collection | UPM |
| description | This study aimed to determine the association between hemoglobin (Hb) concentration and Hb change, during early to mid-pregnancy with the risk of gestational diabetes mellitus (GDM). This was a clinic-based retrospective cohort study of 1951 healthy pregnant women (18–45 years old) with a singleton gestation attending antenatal care at government health clinics. Hb concentration at first prenatal visit and each trimester was extracted from the antenatal cards. Hb changes from first prenatal visit to first and second trimester as well as from second to third trimester were calculated. Multivariate logistic regression was used with adjustment for covariates. Women with GDM had significantly higher Hb concentrations (Hb 1) at first prenatal visit (< 12 weeks) compared with non-GDM women (11·91 g/dl v.11·74 g/dl). Hb 1 and Hb changes (Hb change 2) from first prenatal visit to the second trimester (23–27th weeks) were significantly associated with GDM risk, with an adjusted OR of 1·14 (95 % CI 1·01, 1·29) and 1·25 (95 % CI 1·05, 1·49), respectively. The significant associations between Hb 1 and Hb change 2 with the risk of GDM were found among non-Malays, overweight/obese and women aged 35 years and above. Women with higher Hb concentrations in early pregnancy were at higher risk of GDM, and such association was significant among women aged 35 years and above, non-Malays and overweight/obese. This raises a potential concern for elevated Fe status in early pregnancy as a risk factor of GDM among Fe-replete women. |
| first_indexed | 2024-03-06T11:14:30Z |
| format | Article |
| id | upm.eprints-101036 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:14:30Z |
| publishDate | 2022 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | upm.eprints-1010362023-06-19T06:24:09Z http://psasir.upm.edu.my/id/eprint/101036/ Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study Heng, Yaw Yong Mohd Shariff, Zalilah Mohd Yusof, Barakatun Nisak Rejali, Zulida Yee, Yvonne Siang Tee Bindels, Jacques van der Beek, Eline M. This study aimed to determine the association between hemoglobin (Hb) concentration and Hb change, during early to mid-pregnancy with the risk of gestational diabetes mellitus (GDM). This was a clinic-based retrospective cohort study of 1951 healthy pregnant women (18–45 years old) with a singleton gestation attending antenatal care at government health clinics. Hb concentration at first prenatal visit and each trimester was extracted from the antenatal cards. Hb changes from first prenatal visit to first and second trimester as well as from second to third trimester were calculated. Multivariate logistic regression was used with adjustment for covariates. Women with GDM had significantly higher Hb concentrations (Hb 1) at first prenatal visit (< 12 weeks) compared with non-GDM women (11·91 g/dl v.11·74 g/dl). Hb 1 and Hb changes (Hb change 2) from first prenatal visit to the second trimester (23–27th weeks) were significantly associated with GDM risk, with an adjusted OR of 1·14 (95 % CI 1·01, 1·29) and 1·25 (95 % CI 1·05, 1·49), respectively. The significant associations between Hb 1 and Hb change 2 with the risk of GDM were found among non-Malays, overweight/obese and women aged 35 years and above. Women with higher Hb concentrations in early pregnancy were at higher risk of GDM, and such association was significant among women aged 35 years and above, non-Malays and overweight/obese. This raises a potential concern for elevated Fe status in early pregnancy as a risk factor of GDM among Fe-replete women. Cambridge University Press 2022-12-14 Article PeerReviewed Heng, Yaw Yong and Mohd Shariff, Zalilah and Mohd Yusof, Barakatun Nisak and Rejali, Zulida and Yee, Yvonne Siang Tee and Bindels, Jacques and van der Beek, Eline M. (2022) Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study. British Journal of Nutrition, 128 (11). 01-Aug. ISSN 0007-1145; ESSN: 1475-2662 https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/abs/early-pregnancy-hemoglobin-is-associated-with-the-risk-of-gestational-diabetes-mellitus-a-retrospective-cohort-study/3094C85D407260DA415A85C2B4C793E7#article 10.1017/S000711452100502X |
| spellingShingle | Heng, Yaw Yong Mohd Shariff, Zalilah Mohd Yusof, Barakatun Nisak Rejali, Zulida Yee, Yvonne Siang Tee Bindels, Jacques van der Beek, Eline M. Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study |
| title | Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study |
| title_full | Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study |
| title_fullStr | Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study |
| title_full_unstemmed | Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study |
| title_short | Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study |
| title_sort | early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus a retrospective cohort study |
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