Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
Chestnut rose (Rosa Roxburghii) is an endemic fruit in China with many bioactivities. The present study investigated the effect of chestnut rose juice concentrate (CRJC) on the digestibility of normal wheat starch (NWS), with a focus on the interaction between polyphenols and amylose as well as that...
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| Format: | Article |
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Elsevier
2022
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| _version_ | 1825938498203418624 |
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| author | Zhu, Jianzhong Zhang, Bin Tan, Chin Ping Ding, Li Shao, Miao Chen, Chun Fu, Xiong Huang, Qiang |
| author_facet | Zhu, Jianzhong Zhang, Bin Tan, Chin Ping Ding, Li Shao, Miao Chen, Chun Fu, Xiong Huang, Qiang |
| author_sort | Zhu, Jianzhong |
| collection | UPM |
| description | Chestnut rose (Rosa Roxburghii) is an endemic fruit in China with many bioactivities. The present study investigated the effect of chestnut rose juice concentrate (CRJC) on the digestibility of normal wheat starch (NWS), with a focus on the interaction between polyphenols and amylose as well as that between polyphenols and porcine pancreatic α-amylase (PPA). NWS was mixed with CRJC and digestibility was determined using Englyst method. The composition of CRJC was analyzed by ultrahigh performance liquid chromatography-mass spectrometry. Molecular dynamics (MD) was used to study the binding between polyphenols and PPA and between polyphenols and amylose. The results showed that CRJC could significantly increase the resistant starch content. The MD results agreed with previous docking and experimental results regarding the inhibitory effects (IEs) of polyphenols (with galloyl and glycosyl group differences) against α-glucosidase. The MD results also showed that complex polyphenols with greater molecular weights or a high number of hydrogen bond donors (HBDs)/acceptors (HBAs) bind in a stronger and more lasting manner with amylose than simple polyphenols. CRJC has the potential to reduce the risk of developing type 2 diabetes and molecular simulation can be a supporting tool to study mechanisms in food system. |
| first_indexed | 2024-03-06T11:14:47Z |
| format | Article |
| id | upm.eprints-101138 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:14:47Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-1011382023-05-23T02:55:50Z http://psasir.upm.edu.my/id/eprint/101138/ Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling Zhu, Jianzhong Zhang, Bin Tan, Chin Ping Ding, Li Shao, Miao Chen, Chun Fu, Xiong Huang, Qiang Chestnut rose (Rosa Roxburghii) is an endemic fruit in China with many bioactivities. The present study investigated the effect of chestnut rose juice concentrate (CRJC) on the digestibility of normal wheat starch (NWS), with a focus on the interaction between polyphenols and amylose as well as that between polyphenols and porcine pancreatic α-amylase (PPA). NWS was mixed with CRJC and digestibility was determined using Englyst method. The composition of CRJC was analyzed by ultrahigh performance liquid chromatography-mass spectrometry. Molecular dynamics (MD) was used to study the binding between polyphenols and PPA and between polyphenols and amylose. The results showed that CRJC could significantly increase the resistant starch content. The MD results agreed with previous docking and experimental results regarding the inhibitory effects (IEs) of polyphenols (with galloyl and glycosyl group differences) against α-glucosidase. The MD results also showed that complex polyphenols with greater molecular weights or a high number of hydrogen bond donors (HBDs)/acceptors (HBAs) bind in a stronger and more lasting manner with amylose than simple polyphenols. CRJC has the potential to reduce the risk of developing type 2 diabetes and molecular simulation can be a supporting tool to study mechanisms in food system. Elsevier 2022-02 Article PeerReviewed Zhu, Jianzhong and Zhang, Bin and Tan, Chin Ping and Ding, Li and Shao, Miao and Chen, Chun and Fu, Xiong and Huang, Qiang (2022) Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling. Food Hydrocolloids, 123. art. no. 106966. pp. 1-9. ISSN 0268-005X https://www.sciencedirect.com/science/article/pii/S0268005X21003829 10.1016/j.foodhyd.2021.106966 |
| spellingShingle | Zhu, Jianzhong Zhang, Bin Tan, Chin Ping Ding, Li Shao, Miao Chen, Chun Fu, Xiong Huang, Qiang Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling |
| title | Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling |
| title_full | Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling |
| title_fullStr | Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling |
| title_full_unstemmed | Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling |
| title_short | Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling |
| title_sort | effect of rosa roxburghii juice on starch digestibility a focus on the binding of polyphenols to amylose and porcine pancreatic α amylase by molecular modeling |
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