Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
This paper aims to update the molecular status of porcine circovirus 2 (PCV2) in Malaysia. Firstly, the molecular detection rate of PCV2 in farm and sampled pig population were reported to be 83.78% (31/37 farms) and 83.54% (66/79 pigs) positive for PCV2, respectively. PCV2 was detected across all a...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2022
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| _version_ | 1796984086704685056 |
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| author | Tan, Chew Yee Thanawongnuwech, Roongroje Arshad, Siti Suri Hassan, Latiffah Wai, Michelle Cheng Fong Ooi, Peck Toung |
| author_facet | Tan, Chew Yee Thanawongnuwech, Roongroje Arshad, Siti Suri Hassan, Latiffah Wai, Michelle Cheng Fong Ooi, Peck Toung |
| author_sort | Tan, Chew Yee |
| collection | UPM |
| description | This paper aims to update the molecular status of porcine circovirus 2 (PCV2) in Malaysia. Firstly, the molecular detection rate of PCV2 in farm and sampled pig population were reported to be 83.78% (31/37 farms) and 83.54% (66/79 pigs) positive for PCV2, respectively. PCV2 was detected across all age groups, from fetuses, porkers to sows. Co-detection of PCV2 and PCV3 antigens was also reported at a rate of 28.77% (21/73). Secondly, PCV2 antigen was also detected in Malaysian abattoir lung samples: 18 out of 19 (94.74%) samples originating from clinically healthy finishers were tested positive. Further, this is the first study to confirm the circulation of PCV2 in the wild boar population roaming Peninsular Malaysia, where 28 out of 28 (100%) wild boar lung samples were found positive. One decade earlier, only genotype PCV2b was reported in Malaysia. This most recent update revealed that genotypes PCV2a, PCV2b and PCV2d were present, with PCV2d being the predominant circulating genotype. PCV2 cap gene nucleotide sequences in this study were found to be under negative selection pressure, with an estimated substitution rate of 1.102 × 10−3 substitutions/site/year (ssy). |
| first_indexed | 2024-03-06T11:15:37Z |
| format | Article |
| id | upm.eprints-101621 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:15:37Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-1016212023-08-11T08:40:17Z http://psasir.upm.edu.my/id/eprint/101621/ Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade Tan, Chew Yee Thanawongnuwech, Roongroje Arshad, Siti Suri Hassan, Latiffah Wai, Michelle Cheng Fong Ooi, Peck Toung This paper aims to update the molecular status of porcine circovirus 2 (PCV2) in Malaysia. Firstly, the molecular detection rate of PCV2 in farm and sampled pig population were reported to be 83.78% (31/37 farms) and 83.54% (66/79 pigs) positive for PCV2, respectively. PCV2 was detected across all age groups, from fetuses, porkers to sows. Co-detection of PCV2 and PCV3 antigens was also reported at a rate of 28.77% (21/73). Secondly, PCV2 antigen was also detected in Malaysian abattoir lung samples: 18 out of 19 (94.74%) samples originating from clinically healthy finishers were tested positive. Further, this is the first study to confirm the circulation of PCV2 in the wild boar population roaming Peninsular Malaysia, where 28 out of 28 (100%) wild boar lung samples were found positive. One decade earlier, only genotype PCV2b was reported in Malaysia. This most recent update revealed that genotypes PCV2a, PCV2b and PCV2d were present, with PCV2d being the predominant circulating genotype. PCV2 cap gene nucleotide sequences in this study were found to be under negative selection pressure, with an estimated substitution rate of 1.102 × 10−3 substitutions/site/year (ssy). Multidisciplinary Digital Publishing Institute 2022-07-21 Article PeerReviewed Tan, Chew Yee and Thanawongnuwech, Roongroje and Arshad, Siti Suri and Hassan, Latiffah and Wai, Michelle Cheng Fong and Ooi, Peck Toung (2022) Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade. Animals, 12 (14). art. no. 1849. pp. 1-21. ISSN 2076-2615 https://www.mdpi.com/2076-2615/12/14/1849 10.3390/ani12141849 |
| spellingShingle | Tan, Chew Yee Thanawongnuwech, Roongroje Arshad, Siti Suri Hassan, Latiffah Wai, Michelle Cheng Fong Ooi, Peck Toung Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade |
| title | Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade |
| title_full | Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade |
| title_fullStr | Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade |
| title_full_unstemmed | Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade |
| title_short | Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade |
| title_sort | genotype shift of malaysian porcine circovirus 2 pcv2 from pcv2b to pcv2d within a decade |
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