Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
Vesicular carrier system, niosome, has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and ant...
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| Format: | Article |
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Universiti Malaysia Terengganu
2022
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| _version_ | 1796984150907944960 |
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| author | Ab Aziz, Noor Atikah Salim, Norazlinaliza Saari, Nazamid Md. Yusoff, Fatimah Zarei, Mohammad |
| author_facet | Ab Aziz, Noor Atikah Salim, Norazlinaliza Saari, Nazamid Md. Yusoff, Fatimah Zarei, Mohammad |
| author_sort | Ab Aziz, Noor Atikah |
| collection | UPM |
| description | Vesicular carrier system, niosome, has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and antibacterial properties. Niosomes, which are composed of a mixture of non-ionic surfactants, was prepared by using coacervation and sonication techniques optimized using a D-optimal mixture experimental design (MED) to obtain a small particle size. The particle size of the niosome obtained was 111.2 nm with a polydispersity index (PDI) value of 0.256 and a zeta potential value of −6.62 mV. Transmission Electron Microscopy (TEM) study showed the formation of spherical bilayer vesicle with a size correlating well with Zetasizer analysis. The stability of the niosome formulation was studied over a 60-day period, during which changes in particle size from 104.5 to 386.5 nm were observed. The results showed no phase separation or creaming. Niosome obtained from this study was shown to exhibit antioxidant (65.9% DPPH scavenging activity and 34.6% metal chelating activity) and exhibited inhibitory activity against Staphylococcus aureus (up to 98.8%). The optimized niosome might be suitable for topical application. |
| first_indexed | 2024-03-06T11:16:25Z |
| format | Article |
| id | upm.eprints-102025 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:16:25Z |
| publishDate | 2022 |
| publisher | Universiti Malaysia Terengganu |
| record_format | dspace |
| spelling | upm.eprints-1020252023-10-06T23:14:12Z http://psasir.upm.edu.my/id/eprint/102025/ Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities Ab Aziz, Noor Atikah Salim, Norazlinaliza Saari, Nazamid Md. Yusoff, Fatimah Zarei, Mohammad Vesicular carrier system, niosome, has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and antibacterial properties. Niosomes, which are composed of a mixture of non-ionic surfactants, was prepared by using coacervation and sonication techniques optimized using a D-optimal mixture experimental design (MED) to obtain a small particle size. The particle size of the niosome obtained was 111.2 nm with a polydispersity index (PDI) value of 0.256 and a zeta potential value of −6.62 mV. Transmission Electron Microscopy (TEM) study showed the formation of spherical bilayer vesicle with a size correlating well with Zetasizer analysis. The stability of the niosome formulation was studied over a 60-day period, during which changes in particle size from 104.5 to 386.5 nm were observed. The results showed no phase separation or creaming. Niosome obtained from this study was shown to exhibit antioxidant (65.9% DPPH scavenging activity and 34.6% metal chelating activity) and exhibited inhibitory activity against Staphylococcus aureus (up to 98.8%). The optimized niosome might be suitable for topical application. Universiti Malaysia Terengganu 2022 Article PeerReviewed Ab Aziz, Noor Atikah and Salim, Norazlinaliza and Saari, Nazamid and Md. Yusoff, Fatimah and Zarei, Mohammad (2022) Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities. Journal of Sustainability Science and Management, 17 (2). pp. 1-17. ISSN 1823-8556; ESSN: 2672-7226 https://jssm.umt.edu.my/?page_id=4696 10.46754/jssm.2022.02.001 |
| spellingShingle | Ab Aziz, Noor Atikah Salim, Norazlinaliza Saari, Nazamid Md. Yusoff, Fatimah Zarei, Mohammad Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities |
| title | Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities |
| title_full | Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities |
| title_fullStr | Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities |
| title_full_unstemmed | Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities |
| title_short | Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities |
| title_sort | jellyfish collagen hydrolysate loaded niosome for topical application formulation development antioxidant and antibacterial activities |
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