Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
Pesticides are known as potential mutagens as their ingredients may prompt mutations, alter chromosomes, and cause deoxyribonucleic acid (DNA) damage. Biomarker is a common tool used to assess health effects and exposure level. This paper reviewed studies from 2010 to 2020 on pesticides exposure and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/102183/1/2022041110264114_1056.pdf |
| _version_ | 1796984180181041152 |
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| author | Abd Rahman, Alia Azwa Ho, Yu Bin Nordin, Norshariza Sin, Eugenie Sing Tan Abdullah, Rozaini |
| author_facet | Abd Rahman, Alia Azwa Ho, Yu Bin Nordin, Norshariza Sin, Eugenie Sing Tan Abdullah, Rozaini |
| author_sort | Abd Rahman, Alia Azwa |
| collection | UPM |
| description | Pesticides are known as potential mutagens as their ingredients may prompt mutations, alter chromosomes, and cause deoxyribonucleic acid (DNA) damage. Biomarker is a common tool used to assess health effects and exposure level. This paper reviewed studies from 2010 to 2020 on pesticides exposure and DNA damage. Seven commonly used biomarkers were comet assay parameters, micronucleus (MN), nuclear buds (NBUD), nucleoplasmic bridges (NPB), 8-hydroxy-2-deoxyguanosine (8-OHdG), telomere length, and chromosomal aberrations (CA). The use of these biomarkers was evaluated with their advantages and disadvantages, as well as population exposed. Based on the findings, biomarkers have shown promising results as precursors of DNA damages. The associations between pesticide and DNA damage were equivocal, but most studies showed increment in genetic damages in exposed versus non-exposed population. These biomarkers can serve as predictive marker for risk of initiation and development of cancers or other chronic diseases. |
| first_indexed | 2024-03-06T11:16:49Z |
| format | Article |
| id | upm.eprints-102183 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:16:49Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences |
| record_format | dspace |
| spelling | upm.eprints-1021832023-08-11T08:23:18Z http://psasir.upm.edu.my/id/eprint/102183/ Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review Abd Rahman, Alia Azwa Ho, Yu Bin Nordin, Norshariza Sin, Eugenie Sing Tan Abdullah, Rozaini Pesticides are known as potential mutagens as their ingredients may prompt mutations, alter chromosomes, and cause deoxyribonucleic acid (DNA) damage. Biomarker is a common tool used to assess health effects and exposure level. This paper reviewed studies from 2010 to 2020 on pesticides exposure and DNA damage. Seven commonly used biomarkers were comet assay parameters, micronucleus (MN), nuclear buds (NBUD), nucleoplasmic bridges (NPB), 8-hydroxy-2-deoxyguanosine (8-OHdG), telomere length, and chromosomal aberrations (CA). The use of these biomarkers was evaluated with their advantages and disadvantages, as well as population exposed. Based on the findings, biomarkers have shown promising results as precursors of DNA damages. The associations between pesticide and DNA damage were equivocal, but most studies showed increment in genetic damages in exposed versus non-exposed population. These biomarkers can serve as predictive marker for risk of initiation and development of cancers or other chronic diseases. Faculty of Medicine and Health Sciences 2022 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/102183/1/2022041110264114_1056.pdf Abd Rahman, Alia Azwa and Ho, Yu Bin and Nordin, Norshariza and Sin, Eugenie Sing Tan and Abdullah, Rozaini (2022) Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review. Malaysian Journal of Medicine and Health Sciences, 18 (suppl.5). 120 - 125. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_18_2022/mjmhs_vol18_supp_5_april_2022-66369 |
| spellingShingle | Abd Rahman, Alia Azwa Ho, Yu Bin Nordin, Norshariza Sin, Eugenie Sing Tan Abdullah, Rozaini Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review |
| title | Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review |
| title_full | Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review |
| title_fullStr | Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review |
| title_full_unstemmed | Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review |
| title_short | Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review |
| title_sort | minimally invasive sampling sources for quality and quantity of dna for telomere length measurement a review |
| url | http://psasir.upm.edu.my/id/eprint/102183/1/2022041110264114_1056.pdf |
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