Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections
Fowlpox is a common viral disease caused by fowlpox virus (FWPV), which infects birds. Fowlpox is an important disease in commercial poultry farming, as it can affect many production-system variables, such as size, performance and viability. Studies on the interactions between chicken bone marrow-de...
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| Format: | Article |
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ResearchersLinks
2022
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| author | Mohamad Abir, Anis Suraya Yusof, Sakinah Abd Rahaman, Yasmin Omar, Abdul Rahman Ho, Kok Lian Tan, Wen Siang Mariatulqabtiah, Abdul Razak |
| author_facet | Mohamad Abir, Anis Suraya Yusof, Sakinah Abd Rahaman, Yasmin Omar, Abdul Rahman Ho, Kok Lian Tan, Wen Siang Mariatulqabtiah, Abdul Razak |
| author_sort | Mohamad Abir, Anis Suraya |
| collection | UPM |
| description | Fowlpox is a common viral disease caused by fowlpox virus (FWPV), which infects birds. Fowlpox is an important disease in commercial poultry farming, as it can affect many production-system variables, such as size, performance and viability. Studies on the interactions between chicken bone marrow-derived dendritic cells (chBM-DCs) and FWPV and its recombinant viruses are limited compared to other avian viral infectious diseases. Therefore, this study characterised the response of chBM-DCs to infection with the wild-type (WT) FP9 strain of FWPV compared to a recombinant FWPV carrying the H5 gene of avian influenza virus (rFWPV-H5) using morphological and immunophenotypical observations. The results showed that the rFWPV-H5-infected chBM-DCs formed better dendrites and stellate cells, compared to the WT FWPV. The recombinant virus also expressed higher levels of the surface markers CD86 and MHC class II double-positive chBM-DCs 12 and 24 h post-infection. In conclusion, chBM-DCs were susceptible to WT FWPV and rFWPV-H5 infections, where the recombinant virus induced phenotypic maturation of the cells better than the WT virus. This study supports further understanding of the innate immune response after FWPV infection in chickens. |
| first_indexed | 2024-03-06T11:16:57Z |
| format | Article |
| id | upm.eprints-102240 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:16:57Z |
| publishDate | 2022 |
| publisher | ResearchersLinks |
| record_format | dspace |
| spelling | upm.eprints-1022402023-07-10T00:57:32Z http://psasir.upm.edu.my/id/eprint/102240/ Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections Mohamad Abir, Anis Suraya Yusof, Sakinah Abd Rahaman, Yasmin Omar, Abdul Rahman Ho, Kok Lian Tan, Wen Siang Mariatulqabtiah, Abdul Razak Fowlpox is a common viral disease caused by fowlpox virus (FWPV), which infects birds. Fowlpox is an important disease in commercial poultry farming, as it can affect many production-system variables, such as size, performance and viability. Studies on the interactions between chicken bone marrow-derived dendritic cells (chBM-DCs) and FWPV and its recombinant viruses are limited compared to other avian viral infectious diseases. Therefore, this study characterised the response of chBM-DCs to infection with the wild-type (WT) FP9 strain of FWPV compared to a recombinant FWPV carrying the H5 gene of avian influenza virus (rFWPV-H5) using morphological and immunophenotypical observations. The results showed that the rFWPV-H5-infected chBM-DCs formed better dendrites and stellate cells, compared to the WT FWPV. The recombinant virus also expressed higher levels of the surface markers CD86 and MHC class II double-positive chBM-DCs 12 and 24 h post-infection. In conclusion, chBM-DCs were susceptible to WT FWPV and rFWPV-H5 infections, where the recombinant virus induced phenotypic maturation of the cells better than the WT virus. This study supports further understanding of the innate immune response after FWPV infection in chickens. ResearchersLinks 2022-05-15 Article PeerReviewed Mohamad Abir, Anis Suraya and Yusof, Sakinah and Abd Rahaman, Yasmin and Omar, Abdul Rahman and Ho, Kok Lian and Tan, Wen Siang and Mariatulqabtiah, Abdul Razak (2022) Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections. Advances in Animal and Veterinary Sciences, 10 (6). 1233 - 1238. ISSN 2309-3331; ESSN: 2307-8316 http://researcherslinks.com/current-issues/Morphological-and-Immunophenotypical-Properties-of-Chicken-Bone-Marrow-Derived-Dendritic-Cells-Towards-Wild-Type-and-H5-Recombinant-Fowlpox-Virus-Infections/33/3/4991/html 10.17582/journal.aavs/2022/10.6.1233.1238 |
| spellingShingle | Mohamad Abir, Anis Suraya Yusof, Sakinah Abd Rahaman, Yasmin Omar, Abdul Rahman Ho, Kok Lian Tan, Wen Siang Mariatulqabtiah, Abdul Razak Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections |
| title | Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections |
| title_full | Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections |
| title_fullStr | Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections |
| title_full_unstemmed | Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections |
| title_short | Morphological and immunophenotypical properties of chicken bone marrow-derived dendritic cells towards wild type and H5-recombinant fowlpox virus infections |
| title_sort | morphological and immunophenotypical properties of chicken bone marrow derived dendritic cells towards wild type and h5 recombinant fowlpox virus infections |
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