Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therape...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2022
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| _version_ | 1796984197400756224 |
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| author | Barzegar Behrooz, Amir Talaie, Zahra Syahir, Amir |
| author_facet | Barzegar Behrooz, Amir Talaie, Zahra Syahir, Amir |
| author_sort | Barzegar Behrooz, Amir |
| collection | UPM |
| description | Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therapeutic success for GBM has been restricted. Drug delivery based on nanocarriers and nanotechnology has the potential to be a handy tool in the continuing effort to combat the challenges of treating GBM. There are various new therapies being tested to extend survival time. Maximizing therapeutic effectiveness necessitates using many treatment modalities at once. In the fight against GBM, combination treatments outperform individual ones. Combination therapies may be enhanced by using nanotechnology-based delivery techniques. Nano-chemotherapy, nano-chemotherapy–radiation, nano-chemotherapy–phototherapy, and nano-chemotherapy–immunotherapy for GBM are the focus of the current review to shed light on the current status of innovative designs. |
| first_indexed | 2024-03-06T11:17:04Z |
| format | Article |
| id | upm.eprints-102279 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:17:04Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-1022792023-06-15T21:31:57Z http://psasir.upm.edu.my/id/eprint/102279/ Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable Barzegar Behrooz, Amir Talaie, Zahra Syahir, Amir Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therapeutic success for GBM has been restricted. Drug delivery based on nanocarriers and nanotechnology has the potential to be a handy tool in the continuing effort to combat the challenges of treating GBM. There are various new therapies being tested to extend survival time. Maximizing therapeutic effectiveness necessitates using many treatment modalities at once. In the fight against GBM, combination treatments outperform individual ones. Combination therapies may be enhanced by using nanotechnology-based delivery techniques. Nano-chemotherapy, nano-chemotherapy–radiation, nano-chemotherapy–phototherapy, and nano-chemotherapy–immunotherapy for GBM are the focus of the current review to shed light on the current status of innovative designs. Multidisciplinary Digital Publishing Institute 2022-08-15 Article PeerReviewed Barzegar Behrooz, Amir and Talaie, Zahra and Syahir, Amir (2022) Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable. Pharmaceutics, 14 (8). art. no. 1697. pp. 1-23. ISSN 1999-4923 https://www.mdpi.com/1999-4923/14/8/1697# 10.3390/pharmaceutics14081697 |
| spellingShingle | Barzegar Behrooz, Amir Talaie, Zahra Syahir, Amir Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable |
| title | Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable |
| title_full | Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable |
| title_fullStr | Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable |
| title_full_unstemmed | Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable |
| title_short | Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable |
| title_sort | nanotechnology based combinatorial anti glioblastoma therapies moving from terminal to treatable |
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