Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of the new generation of anti-CCP antibodies (anti-CCP2 IgG, ant...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Science, Universiti Putra Malaysia
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/105583/1/2023011613163113_MJMHS_0468.pdf |
| _version_ | 1825939219782041600 |
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| author | Azalan, Maryam Syahidah Wan Mohamad, Wan Majdiah Saddki, Norkhafizah Wan Ghazali, Wan Syamimee |
| author_facet | Azalan, Maryam Syahidah Wan Mohamad, Wan Majdiah Saddki, Norkhafizah Wan Ghazali, Wan Syamimee |
| author_sort | Azalan, Maryam Syahidah |
| collection | UPM |
| description | Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of the new generation of anti-CCP antibodies (anti-CCP2 IgG, anti-CCP2 IgA and anti-CCP3.1 IgG/IgA) and their association with disease severity and functional status of RA patients. Methods: A total of 46 RA patients and 40 healthy controls participated in this cross-sectional study that was conducted at the Rheumatology Clinic, Hospital Universiti Sains Malaysia. Blood samples were taken from all participants for anti-CCP2 IgG, anti-CCP2 IgA, and anti-CCP3.1 IgG/IgA analysis. Disease severity and functional status of RA patients were measured using the Disease Activity Score-28 (DAS28) and the modified Health Assessment Questionnaire (mHAQ) respectively. Results: Significantly higher proportion of RA patients were found with positive anti-CCP2 IgG (63.0%), anti-CCP2 IgA (37.0%), and anti-CCP3.1 IgG/IgA antibodies (63.0%) than the healthy controls. No significant association was found between anti-CCP antibodies status and mean DAS28 score of the RA patients. However, RA patients with negative anti-CCP2 IgG status had higher mean mHAQ score than patients with positive anti-CCP2 IgG status. Conclusion: Our study has demonstrated detection of the new generation anti-CCP antibodies in RA patients, supporting the use of autoantibodies in RA diagnosis. While no significant association was found between the presence of anti-CCP antibodies and disease severity of RA patients, the absence of anti-CCP2 IgG was associated with worse function and greater disability of the patients. |
| first_indexed | 2024-03-06T11:23:14Z |
| format | Article |
| id | upm.eprints-105583 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:23:14Z |
| publishDate | 2023 |
| publisher | Faculty of Medicine and Health Science, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-1055832024-01-29T03:00:19Z http://psasir.upm.edu.my/id/eprint/105583/ Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients Azalan, Maryam Syahidah Wan Mohamad, Wan Majdiah Saddki, Norkhafizah Wan Ghazali, Wan Syamimee Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of the new generation of anti-CCP antibodies (anti-CCP2 IgG, anti-CCP2 IgA and anti-CCP3.1 IgG/IgA) and their association with disease severity and functional status of RA patients. Methods: A total of 46 RA patients and 40 healthy controls participated in this cross-sectional study that was conducted at the Rheumatology Clinic, Hospital Universiti Sains Malaysia. Blood samples were taken from all participants for anti-CCP2 IgG, anti-CCP2 IgA, and anti-CCP3.1 IgG/IgA analysis. Disease severity and functional status of RA patients were measured using the Disease Activity Score-28 (DAS28) and the modified Health Assessment Questionnaire (mHAQ) respectively. Results: Significantly higher proportion of RA patients were found with positive anti-CCP2 IgG (63.0%), anti-CCP2 IgA (37.0%), and anti-CCP3.1 IgG/IgA antibodies (63.0%) than the healthy controls. No significant association was found between anti-CCP antibodies status and mean DAS28 score of the RA patients. However, RA patients with negative anti-CCP2 IgG status had higher mean mHAQ score than patients with positive anti-CCP2 IgG status. Conclusion: Our study has demonstrated detection of the new generation anti-CCP antibodies in RA patients, supporting the use of autoantibodies in RA diagnosis. While no significant association was found between the presence of anti-CCP antibodies and disease severity of RA patients, the absence of anti-CCP2 IgG was associated with worse function and greater disability of the patients. Faculty of Medicine and Health Science, Universiti Putra Malaysia 2023-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/105583/1/2023011613163113_MJMHS_0468.pdf Azalan, Maryam Syahidah and Wan Mohamad, Wan Majdiah and Saddki, Norkhafizah and Wan Ghazali, Wan Syamimee (2023) Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients. Malaysian Journal of Medicine and Health Sciences, 19 (1). pp. 96-101. ISSN 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_1_january_2023-70882 10.47836/mjmhs19.1.14 |
| spellingShingle | Azalan, Maryam Syahidah Wan Mohamad, Wan Majdiah Saddki, Norkhafizah Wan Ghazali, Wan Syamimee Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients |
| title | Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients |
| title_full | Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients |
| title_fullStr | Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients |
| title_full_unstemmed | Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients |
| title_short | Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients |
| title_sort | association of new generation anti ccp antibodies with disease severity and functional status in rheumatoid arthritis patients |
| url | http://psasir.upm.edu.my/id/eprint/105583/1/2023011613163113_MJMHS_0468.pdf |
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