Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective
The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillanc...
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| Format: | Article |
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Universiti Sains Malaysia Press
2023
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| _version_ | 1825939443930890240 |
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| author | Amat Junaidi, Nor Syaza Syahirah Mohamed Shakrin, Nik Noorul Shakira Mohd Desa, Mohd Nasir Wan Yunus, Wan Md Zin |
| author_facet | Amat Junaidi, Nor Syaza Syahirah Mohamed Shakrin, Nik Noorul Shakira Mohd Desa, Mohd Nasir Wan Yunus, Wan Md Zin |
| author_sort | Amat Junaidi, Nor Syaza Syahirah |
| collection | UPM |
| description | The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillance of MRSA clones is important to understand their evolutionary dynamics for investigating outbreaks, propagating precautionary measures, as well as planning for appropriate treatment. This review includes peer-reviewed reports on the molecular characterisation of clinical Staphylococcus aureus isolates within Malaysian hospitals from year 2008 to 2020. This work highlights the molecular clones of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) isolates from Malaysian hospitals, with description on their ever-changing pattern. Among HA-MRSA, the ST22-t032-SCCmec IV MRSA clone was reported to supplant the previous dominating clone, ST239-t037-SCCmec III. Meanwhile, ST30, ST772, ST6 and ST22 were repeatedly detected in CA-MRSA, however, none of the strains became predominant. Future in-depth study on molecular epidemiology of MRSA clone is essential for the investigation of the extent of the clonal shift, especially in Malaysia. |
| first_indexed | 2024-12-09T02:18:35Z |
| format | Article |
| id | upm.eprints-107365 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-12-09T02:18:35Z |
| publishDate | 2023 |
| publisher | Universiti Sains Malaysia Press |
| record_format | dspace |
| spelling | upm.eprints-1073652024-10-15T06:42:05Z http://psasir.upm.edu.my/id/eprint/107365/ Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective Amat Junaidi, Nor Syaza Syahirah Mohamed Shakrin, Nik Noorul Shakira Mohd Desa, Mohd Nasir Wan Yunus, Wan Md Zin The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillance of MRSA clones is important to understand their evolutionary dynamics for investigating outbreaks, propagating precautionary measures, as well as planning for appropriate treatment. This review includes peer-reviewed reports on the molecular characterisation of clinical Staphylococcus aureus isolates within Malaysian hospitals from year 2008 to 2020. This work highlights the molecular clones of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) isolates from Malaysian hospitals, with description on their ever-changing pattern. Among HA-MRSA, the ST22-t032-SCCmec IV MRSA clone was reported to supplant the previous dominating clone, ST239-t037-SCCmec III. Meanwhile, ST30, ST772, ST6 and ST22 were repeatedly detected in CA-MRSA, however, none of the strains became predominant. Future in-depth study on molecular epidemiology of MRSA clone is essential for the investigation of the extent of the clonal shift, especially in Malaysia. Universiti Sains Malaysia Press 2023-04 Article PeerReviewed Amat Junaidi, Nor Syaza Syahirah and Mohamed Shakrin, Nik Noorul Shakira and Mohd Desa, Mohd Nasir and Wan Yunus, Wan Md Zin (2023) Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective. Malaysian Journal of Medical Science, 30 (2). pp. 26-41. ISSN 1394-195X; ESSN: 2180-4303 http://www.mjms.usm.my/MJMS30022023/MJMS30022023_03.pdf 10.21315/mjms2023.30.2.3 |
| spellingShingle | Amat Junaidi, Nor Syaza Syahirah Mohamed Shakrin, Nik Noorul Shakira Mohd Desa, Mohd Nasir Wan Yunus, Wan Md Zin Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective |
| title | Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective |
| title_full | Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective |
| title_fullStr | Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective |
| title_full_unstemmed | Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective |
| title_short | Dissemination pattern of hospital-acquired methicillin-resistant Staphylococcus aureus and community-acquired MRSA isolates from Malaysian hospitals: a review from a molecular perspective |
| title_sort | dissemination pattern of hospital acquired methicillin resistant staphylococcus aureus and community acquired mrsa isolates from malaysian hospitals a review from a molecular perspective |
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