Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation
Maternal obesity is a key predictor of childhood obesity and a determining factor for a child’s body composition. Thus, any form of maternal nutrition during the gestational period plays a vital role in influencing the growth of the fetus. Elateriospermum tapos (E. tapos) yogurt has been found to co...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Multidisciplinary Digital Publishing Institute
2024
|
| _version_ | 1825939493604032512 |
|---|---|
| author | Naomi, Ruth Mahmad Rusli, Rusydatul Nabila Othman, Fezah Balan, Santhra Segaran Abidin, Azrina Zainal Embong, Hashim Teoh, Soo Huat Jasni, Azmiza Syawani Jumidil, Siti Hadizah Matraf, Khaled Salem Yaslam Ba Zakaria, Zainul Amiruddin Bahari, Hasnah Yazid, Muhammad Dain |
| author_facet | Naomi, Ruth Mahmad Rusli, Rusydatul Nabila Othman, Fezah Balan, Santhra Segaran Abidin, Azrina Zainal Embong, Hashim Teoh, Soo Huat Jasni, Azmiza Syawani Jumidil, Siti Hadizah Matraf, Khaled Salem Yaslam Ba Zakaria, Zainul Amiruddin Bahari, Hasnah Yazid, Muhammad Dain |
| author_sort | Naomi, Ruth |
| collection | UPM |
| description | Maternal obesity is a key predictor of childhood obesity and a determining factor for a child’s body composition. Thus, any form of maternal nutrition during the gestational period plays a vital role in influencing the growth of the fetus. Elateriospermum tapos (E. tapos) yogurt has been found to comprise many bioactive compounds such as tannins, saponins, α-linolenic acid, and 5′-methoxy-bilobate with apocynoside I that could cross the placenta and exhibit an anti-obesity effect. As such, this study aimed to investigate the role of maternal E. tapos yogurt supplementation on offspring body composition. In this study, 48 female Sprague Dawley (SD) rats were induced with obesity using a high-fat diet (HFD) and were allowed to breed. Upon confirmation of pregnancy, treatment was initiated with E. tapos yogurt on the obese dams up to postnatal day 21. The weaning offspring were then designated into six groups according to their dam’s group (n = 8) as follows; normal food and saline (NS), HFD and saline (HS), HFD and yogurt (HY), HFD and 5 mg/kg of E. tapos yogurt (HYT5), HFD and 50 mg/kg of E. tapos yogurt (HYT50), and HFD and 500 mg/kg of E. tapos yogurt (HYT500). The body weight of the offspring was accessed every 3 days up to PND 21. All the offspring were euthanized on PND 21 for tissue harvesting and blood sample collection. The results showed that both male and female offspring of obese dams treated with E. tapos yogurt showed growth patterns similar to NS and reduced levels of triglycerides (TG), cholesterol, LDL, non-HDL, and leptin. Liver enzymes such as ALT, ALP, AST, GGT, and globulin, and renal markers such as sodium, potassium, chloride, urea, and creatinine levels significantly reduced (p < 0.05) in the offspring of E. tapos yogurt-treated obese dams with the normal histological architecture of the liver, kidney, colon, RpWAT, and visceral tissue that is comparable to NS. In toto, E. tapos yogurt supplementation of obese dams exerted an anti-obesity effect by preventing intergenerational obesity by reversing HFD-induced damage in the fat tissue of the offspring. |
| first_indexed | 2024-09-25T03:40:07Z |
| format | Article |
| id | upm.eprints-107637 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:40:07Z |
| publishDate | 2024 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-1076372024-09-09T04:01:58Z http://psasir.upm.edu.my/id/eprint/107637/ Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation Naomi, Ruth Mahmad Rusli, Rusydatul Nabila Othman, Fezah Balan, Santhra Segaran Abidin, Azrina Zainal Embong, Hashim Teoh, Soo Huat Jasni, Azmiza Syawani Jumidil, Siti Hadizah Matraf, Khaled Salem Yaslam Ba Zakaria, Zainul Amiruddin Bahari, Hasnah Yazid, Muhammad Dain Maternal obesity is a key predictor of childhood obesity and a determining factor for a child’s body composition. Thus, any form of maternal nutrition during the gestational period plays a vital role in influencing the growth of the fetus. Elateriospermum tapos (E. tapos) yogurt has been found to comprise many bioactive compounds such as tannins, saponins, α-linolenic acid, and 5′-methoxy-bilobate with apocynoside I that could cross the placenta and exhibit an anti-obesity effect. As such, this study aimed to investigate the role of maternal E. tapos yogurt supplementation on offspring body composition. In this study, 48 female Sprague Dawley (SD) rats were induced with obesity using a high-fat diet (HFD) and were allowed to breed. Upon confirmation of pregnancy, treatment was initiated with E. tapos yogurt on the obese dams up to postnatal day 21. The weaning offspring were then designated into six groups according to their dam’s group (n = 8) as follows; normal food and saline (NS), HFD and saline (HS), HFD and yogurt (HY), HFD and 5 mg/kg of E. tapos yogurt (HYT5), HFD and 50 mg/kg of E. tapos yogurt (HYT50), and HFD and 500 mg/kg of E. tapos yogurt (HYT500). The body weight of the offspring was accessed every 3 days up to PND 21. All the offspring were euthanized on PND 21 for tissue harvesting and blood sample collection. The results showed that both male and female offspring of obese dams treated with E. tapos yogurt showed growth patterns similar to NS and reduced levels of triglycerides (TG), cholesterol, LDL, non-HDL, and leptin. Liver enzymes such as ALT, ALP, AST, GGT, and globulin, and renal markers such as sodium, potassium, chloride, urea, and creatinine levels significantly reduced (p < 0.05) in the offspring of E. tapos yogurt-treated obese dams with the normal histological architecture of the liver, kidney, colon, RpWAT, and visceral tissue that is comparable to NS. In toto, E. tapos yogurt supplementation of obese dams exerted an anti-obesity effect by preventing intergenerational obesity by reversing HFD-induced damage in the fat tissue of the offspring. Multidisciplinary Digital Publishing Institute 2024-04-30 Article PeerReviewed Naomi, Ruth and Mahmad Rusli, Rusydatul Nabila and Othman, Fezah and Balan, Santhra Segaran and Abidin, Azrina Zainal and Embong, Hashim and Teoh, Soo Huat and Jasni, Azmiza Syawani and Jumidil, Siti Hadizah and Matraf, Khaled Salem Yaslam Ba and Zakaria, Zainul Amiruddin and Bahari, Hasnah and Yazid, Muhammad Dain (2024) Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation. Nutrients, 15 (5). art. no. 1258. ISSN 2072-6643 https://www.mdpi.com/2072-6643/15/5/1258 10.3390/nu15051258 |
| spellingShingle | Naomi, Ruth Mahmad Rusli, Rusydatul Nabila Othman, Fezah Balan, Santhra Segaran Abidin, Azrina Zainal Embong, Hashim Teoh, Soo Huat Jasni, Azmiza Syawani Jumidil, Siti Hadizah Matraf, Khaled Salem Yaslam Ba Zakaria, Zainul Amiruddin Bahari, Hasnah Yazid, Muhammad Dain Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation |
| title | Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation |
| title_full | Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation |
| title_fullStr | Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation |
| title_full_unstemmed | Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation |
| title_short | Elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of F1 generation |
| title_sort | elateriospermum tapos yogurt supplement in maternal obese dams during pregnancy modulates the body composition of f1 generation |
| work_keys_str_mv | AT naomiruth elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT mahmadruslirusydatulnabila elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT othmanfezah elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT balansanthrasegaran elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT abidinazrinazainal elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT embonghashim elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT teohsoohuat elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT jasniazmizasyawani elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT jumidilsitihadizah elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT matrafkhaledsalemyaslamba elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT zakariazainulamiruddin elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT baharihasnah elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation AT yazidmuhammaddain elateriospermumtaposyogurtsupplementinmaternalobesedamsduringpregnancymodulatesthebodycompositionoff1generation |