Flavonoids as potential wound-healing molecules: emphasis on pathways perspective
Wounds are considered to be a serious problem that affects the healthcare sector in many countries, primarily due to diabetes and obesity. Wounds become worse because of unhealthy lifestyles and habits. Wound healing is a complicated physiological process that is essential for restoring the epitheli...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2023
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| _version_ | 1817927539963723776 |
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| author | Zulkefli, Nabilah Che Zahari, Che Nur Mazadillina Sayuti, Nor Hafiza Kamarudin, Ammar Akram Saad, Norazalina Hamezah, Hamizah Shahirah Bunawan, Hamidun Baharum, Syarul Nataqain Mediani, Ahmed Ahmed, Qamar Uddin Harun Ismail, Ahmad Fahmi Sarian, Murni Nazira |
| author_facet | Zulkefli, Nabilah Che Zahari, Che Nur Mazadillina Sayuti, Nor Hafiza Kamarudin, Ammar Akram Saad, Norazalina Hamezah, Hamizah Shahirah Bunawan, Hamidun Baharum, Syarul Nataqain Mediani, Ahmed Ahmed, Qamar Uddin Harun Ismail, Ahmad Fahmi Sarian, Murni Nazira |
| author_sort | Zulkefli, Nabilah |
| collection | UPM |
| description | Wounds are considered to be a serious problem that affects the healthcare sector in many countries, primarily due to diabetes and obesity. Wounds become worse because of unhealthy lifestyles and habits. Wound healing is a complicated physiological process that is essential for restoring the epithelial barrier after an injury. Numerous studies have reported that flavonoids possess wound-healing properties due to their well-acclaimed anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects. They have been shown to be able to act on the wound-healing process via expression of biomarkers respective to the pathways that mainly include Wnt/β-catenin, Hippo, Transforming Growth Factor-beta (TGF-β), Hedgehog, c-Jun N-Terminal Kinase (JNK), NF-E2-related factor 2/antioxidant responsive element (Nrf2/ARE), Nuclear Factor Kappa B (NF-κB), MAPK/ERK, Ras/Raf/MEK/ERK, phosphatidylinositol 3-kinase (PI3K)/Akt, Nitric oxide (NO) pathways, etc. Hence, we have compiled existing evidence on the manipulation of flavonoids towards achieving skin wound healing, together with current limitations and future perspectives in support of these polyphenolic compounds as safe wound-healing agents, in this review. |
| first_indexed | 2024-12-09T02:20:03Z |
| format | Article |
| id | upm.eprints-108021 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-12-09T02:20:03Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-1080212024-09-26T04:23:23Z http://psasir.upm.edu.my/id/eprint/108021/ Flavonoids as potential wound-healing molecules: emphasis on pathways perspective Zulkefli, Nabilah Che Zahari, Che Nur Mazadillina Sayuti, Nor Hafiza Kamarudin, Ammar Akram Saad, Norazalina Hamezah, Hamizah Shahirah Bunawan, Hamidun Baharum, Syarul Nataqain Mediani, Ahmed Ahmed, Qamar Uddin Harun Ismail, Ahmad Fahmi Sarian, Murni Nazira Wounds are considered to be a serious problem that affects the healthcare sector in many countries, primarily due to diabetes and obesity. Wounds become worse because of unhealthy lifestyles and habits. Wound healing is a complicated physiological process that is essential for restoring the epithelial barrier after an injury. Numerous studies have reported that flavonoids possess wound-healing properties due to their well-acclaimed anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects. They have been shown to be able to act on the wound-healing process via expression of biomarkers respective to the pathways that mainly include Wnt/β-catenin, Hippo, Transforming Growth Factor-beta (TGF-β), Hedgehog, c-Jun N-Terminal Kinase (JNK), NF-E2-related factor 2/antioxidant responsive element (Nrf2/ARE), Nuclear Factor Kappa B (NF-κB), MAPK/ERK, Ras/Raf/MEK/ERK, phosphatidylinositol 3-kinase (PI3K)/Akt, Nitric oxide (NO) pathways, etc. Hence, we have compiled existing evidence on the manipulation of flavonoids towards achieving skin wound healing, together with current limitations and future perspectives in support of these polyphenolic compounds as safe wound-healing agents, in this review. Multidisciplinary Digital Publishing Institute 2023 Article PeerReviewed Zulkefli, Nabilah and Che Zahari, Che Nur Mazadillina and Sayuti, Nor Hafiza and Kamarudin, Ammar Akram and Saad, Norazalina and Hamezah, Hamizah Shahirah and Bunawan, Hamidun and Baharum, Syarul Nataqain and Mediani, Ahmed and Ahmed, Qamar Uddin and Harun Ismail, Ahmad Fahmi and Sarian, Murni Nazira (2023) Flavonoids as potential wound-healing molecules: emphasis on pathways perspective. International Journal of Molecular Sciences, 24 (5). art. no. 4607. pp. 1-29. ISSN 1661-6596; ESSN: 1422-0067 https://www.mdpi.com/1422-0067/24/5/4607 10.3390/ijms24054607 |
| spellingShingle | Zulkefli, Nabilah Che Zahari, Che Nur Mazadillina Sayuti, Nor Hafiza Kamarudin, Ammar Akram Saad, Norazalina Hamezah, Hamizah Shahirah Bunawan, Hamidun Baharum, Syarul Nataqain Mediani, Ahmed Ahmed, Qamar Uddin Harun Ismail, Ahmad Fahmi Sarian, Murni Nazira Flavonoids as potential wound-healing molecules: emphasis on pathways perspective |
| title | Flavonoids as potential wound-healing molecules: emphasis on pathways perspective |
| title_full | Flavonoids as potential wound-healing molecules: emphasis on pathways perspective |
| title_fullStr | Flavonoids as potential wound-healing molecules: emphasis on pathways perspective |
| title_full_unstemmed | Flavonoids as potential wound-healing molecules: emphasis on pathways perspective |
| title_short | Flavonoids as potential wound-healing molecules: emphasis on pathways perspective |
| title_sort | flavonoids as potential wound healing molecules emphasis on pathways perspective |
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