Foodomics reveals anti-obesity properties of cannabinoids from hemp oil
Scope Molecular networking (MN) analysis intends to provide chemical insight of untargeted mass spectrometry (MS) data to the user's underlying biological questions. Foodomics is the study of chemical compounds in food using advanced omics methods. In this study, an MS-MN-based foodomics appro...
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| Format: | Article |
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Wiley
2023
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| _version_ | 1825939564890423296 |
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| author | Ding, Ziwen Jiang, Fan Shi, Jiachen Wang, Yanan He, Mengxue Tan, Chin Ping Liu, Yuanfa Xu, Yong‐Jiang |
| author_facet | Ding, Ziwen Jiang, Fan Shi, Jiachen Wang, Yanan He, Mengxue Tan, Chin Ping Liu, Yuanfa Xu, Yong‐Jiang |
| author_sort | Ding, Ziwen |
| collection | UPM |
| description | Scope
Molecular networking (MN) analysis intends to provide chemical insight of untargeted mass spectrometry (MS) data to the user's underlying biological questions. Foodomics is the study of chemical compounds in food using advanced omics methods. In this study, an MS-MN-based foodomics approach is developed to investigate the composition and anti-obesity activity of cannabinoids in hemp oil.
Methods and results
A total of 16 cannabinoids are determined in optimized microwave pretreatment of hemp oil using the developed approach. Untargeted metabolomics analysis reveals that cannabinoid extract (CE) and its major constituent (cannabidiol, CBD), can alleviate high glucose-induced increases in lipids and carbohydrates, and decreases in amino acid and nucleic acid. Moreover, CE and CBD are also found to suppress the expression levels of mdt-15, sbp-1, fat-5, fat-6, fat-7, daf-2, and elevate the expression level of daf-1, daf-7, daf-16, sod-3, gst-4, lipl-4, resulting in the decrease of lipid synthesis and the enhance of kinetism. Canonical correspondence analysis (CCA) uncovers strong associations between specific metabolic alterations and gene expression levels.
Conclusion
These findings from this exploratory study offer a new insight into the roles of cannabinoids in the treatment of obesity and related complications. |
| first_indexed | 2024-12-09T02:20:06Z |
| format | Article |
| id | upm.eprints-108034 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-12-09T02:20:06Z |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | upm.eprints-1080342024-09-26T04:06:47Z http://psasir.upm.edu.my/id/eprint/108034/ Foodomics reveals anti-obesity properties of cannabinoids from hemp oil Ding, Ziwen Jiang, Fan Shi, Jiachen Wang, Yanan He, Mengxue Tan, Chin Ping Liu, Yuanfa Xu, Yong‐Jiang Scope Molecular networking (MN) analysis intends to provide chemical insight of untargeted mass spectrometry (MS) data to the user's underlying biological questions. Foodomics is the study of chemical compounds in food using advanced omics methods. In this study, an MS-MN-based foodomics approach is developed to investigate the composition and anti-obesity activity of cannabinoids in hemp oil. Methods and results A total of 16 cannabinoids are determined in optimized microwave pretreatment of hemp oil using the developed approach. Untargeted metabolomics analysis reveals that cannabinoid extract (CE) and its major constituent (cannabidiol, CBD), can alleviate high glucose-induced increases in lipids and carbohydrates, and decreases in amino acid and nucleic acid. Moreover, CE and CBD are also found to suppress the expression levels of mdt-15, sbp-1, fat-5, fat-6, fat-7, daf-2, and elevate the expression level of daf-1, daf-7, daf-16, sod-3, gst-4, lipl-4, resulting in the decrease of lipid synthesis and the enhance of kinetism. Canonical correspondence analysis (CCA) uncovers strong associations between specific metabolic alterations and gene expression levels. Conclusion These findings from this exploratory study offer a new insight into the roles of cannabinoids in the treatment of obesity and related complications. Wiley 2023 Article PeerReviewed Ding, Ziwen and Jiang, Fan and Shi, Jiachen and Wang, Yanan and He, Mengxue and Tan, Chin Ping and Liu, Yuanfa and Xu, Yong‐Jiang (2023) Foodomics reveals anti-obesity properties of cannabinoids from hemp oil. Molecular Nutrition & Food Research, 67 (2). art. no. 2200508. pp. 1-10. ISSN 1613-4125; ESSN: 1613-4133 https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200508 10.1002/mnfr.202200508 |
| spellingShingle | Ding, Ziwen Jiang, Fan Shi, Jiachen Wang, Yanan He, Mengxue Tan, Chin Ping Liu, Yuanfa Xu, Yong‐Jiang Foodomics reveals anti-obesity properties of cannabinoids from hemp oil |
| title | Foodomics reveals anti-obesity properties of cannabinoids from hemp oil |
| title_full | Foodomics reveals anti-obesity properties of cannabinoids from hemp oil |
| title_fullStr | Foodomics reveals anti-obesity properties of cannabinoids from hemp oil |
| title_full_unstemmed | Foodomics reveals anti-obesity properties of cannabinoids from hemp oil |
| title_short | Foodomics reveals anti-obesity properties of cannabinoids from hemp oil |
| title_sort | foodomics reveals anti obesity properties of cannabinoids from hemp oil |
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