HIF-1 activation and inflammatory responses to hypoxiahypoxia
Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Embry-Riddle Aeronautical University
2023
|
| _version_ | 1825939590824853504 |
|---|---|
| author | Shaharuddin, Shazreen Nik Abd Rahman, Nik Mohd Afizan Masarudin, Mas Jaffri Alamassi, Mohammedarfat N |
| author_facet | Shaharuddin, Shazreen Nik Abd Rahman, Nik Mohd Afizan Masarudin, Mas Jaffri Alamassi, Mohammedarfat N |
| author_sort | Shaharuddin, Shazreen |
| collection | UPM |
| description | Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, or the inability of tissues to utilise oxygen. Different organs are hypoxic due to differences in tissue oxygen tensions, which are determined by differences in aerobic metabolism. Extremely hypoxic individuals have the most dramatic systemic and neurological adaptations to persistent hypoxia. In this review, we provide an overview of central and systemic responses to hypoxia and discuss the activation of HIF-1 pathway. |
| first_indexed | 2024-09-25T03:40:36Z |
| format | Article |
| id | upm.eprints-108172 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:40:36Z |
| publishDate | 2023 |
| publisher | Embry-Riddle Aeronautical University |
| record_format | dspace |
| spelling | upm.eprints-1081722024-09-23T01:57:58Z http://psasir.upm.edu.my/id/eprint/108172/ HIF-1 activation and inflammatory responses to hypoxiahypoxia Shaharuddin, Shazreen Nik Abd Rahman, Nik Mohd Afizan Masarudin, Mas Jaffri Alamassi, Mohammedarfat N Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, or the inability of tissues to utilise oxygen. Different organs are hypoxic due to differences in tissue oxygen tensions, which are determined by differences in aerobic metabolism. Extremely hypoxic individuals have the most dramatic systemic and neurological adaptations to persistent hypoxia. In this review, we provide an overview of central and systemic responses to hypoxia and discuss the activation of HIF-1 pathway. Embry-Riddle Aeronautical University 2023 Article PeerReviewed Shaharuddin, Shazreen and Nik Abd Rahman, Nik Mohd Afizan and Masarudin, Mas Jaffri and Alamassi, Mohammedarfat N (2023) HIF-1 activation and inflammatory responses to hypoxiahypoxia. International Journal of Aviation, Aeronautics, and Aerospace, 10 (2). art. no. 3. pp. 1-12. ISSN 2374-6793 https://commons.erau.edu/ijaaa/vol10/iss2/3/ 10.58940/2374-6793.1798 |
| spellingShingle | Shaharuddin, Shazreen Nik Abd Rahman, Nik Mohd Afizan Masarudin, Mas Jaffri Alamassi, Mohammedarfat N HIF-1 activation and inflammatory responses to hypoxiahypoxia |
| title | HIF-1 activation and inflammatory responses to hypoxiahypoxia |
| title_full | HIF-1 activation and inflammatory responses to hypoxiahypoxia |
| title_fullStr | HIF-1 activation and inflammatory responses to hypoxiahypoxia |
| title_full_unstemmed | HIF-1 activation and inflammatory responses to hypoxiahypoxia |
| title_short | HIF-1 activation and inflammatory responses to hypoxiahypoxia |
| title_sort | hif 1 activation and inflammatory responses to hypoxiahypoxia |
| work_keys_str_mv | AT shaharuddinshazreen hif1activationandinflammatoryresponsestohypoxiahypoxia AT nikabdrahmannikmohdafizan hif1activationandinflammatoryresponsestohypoxiahypoxia AT masarudinmasjaffri hif1activationandinflammatoryresponsestohypoxiahypoxia AT alamassimohammedarfatn hif1activationandinflammatoryresponsestohypoxiahypoxia |