Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen specie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108360/1/108360.pdf |
| _version_ | 1825939622483460096 |
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| author | Low, Zhao Xuan Tan, Kai Li Keong, Yong Yoke Looi, Chung Yeng Ooi, Yin Yin |
| author_facet | Low, Zhao Xuan Tan, Kai Li Keong, Yong Yoke Looi, Chung Yeng Ooi, Yin Yin |
| author_sort | Low, Zhao Xuan |
| collection | UPM |
| description | Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1 were used in the current study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 of TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06 and 49.16±0.63, respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH on microglial activation. |
| first_indexed | 2024-12-09T02:20:18Z |
| format | Article |
| id | upm.eprints-108360 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-12-09T02:20:18Z |
| publishDate | 2023 |
| publisher | Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-1083602024-10-24T07:26:09Z http://psasir.upm.edu.my/id/eprint/108360/ Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia Low, Zhao Xuan Tan, Kai Li Keong, Yong Yoke Looi, Chung Yeng Ooi, Yin Yin Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1 were used in the current study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 of TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06 and 49.16±0.63, respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH on microglial activation. Universiti Putra Malaysia 2023-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/108360/1/108360.pdf Low, Zhao Xuan and Tan, Kai Li and Keong, Yong Yoke and Looi, Chung Yeng and Ooi, Yin Yin (2023) Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia. Malaysian Journal of Medicine and Health Sciences, 19 (3). pp. 375-379. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_3_may_2023-72844 10.47836/mjmhs.19.3.47 |
| spellingShingle | Low, Zhao Xuan Tan, Kai Li Keong, Yong Yoke Looi, Chung Yeng Ooi, Yin Yin Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia |
| title | Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia |
| title_full | Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia |
| title_fullStr | Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia |
| title_full_unstemmed | Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia |
| title_short | Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia |
| title_sort | tualang and kelulut honey reduced lipopolysaccharides stimulated inflammatory responses of microglia |
| url | http://psasir.upm.edu.my/id/eprint/108360/1/108360.pdf |
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