Vaccine development for leptospirosis: a systematic review
Objective: To assess the efficacy of various types of vaccines developed for leptospirosis. Methods: A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria...
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| Format: | Article |
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Medknow Publications
2023
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| _version_ | 1811137859402334208 |
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| author | Surendran, Yocyny Nandikha, Mahalingam Amin-Nordin, Syafinaz Dhanda, Sandeep Kumar Mohd Ali, Mohamad Ridhuan Joseph, Narcisse Ms |
| author_facet | Surendran, Yocyny Nandikha, Mahalingam Amin-Nordin, Syafinaz Dhanda, Sandeep Kumar Mohd Ali, Mohamad Ridhuan Joseph, Narcisse Ms |
| author_sort | Surendran, Yocyny |
| collection | UPM |
| description | Objective: To assess the efficacy of various types of vaccines developed for leptospirosis. Methods: A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria are all Leptospira species regardless of any cluster (pathogenic, intermediate and non-pathogenic). This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine candidates. The studies on the effectiveness of outer membrane protein as vaccine candidates were also included. The articles obtained in the databases were imported into the WPS spreadsheet, and duplicate documents were removed manually. Results: A total of 24 studies were included in the review, which evaluated various types of leptospirosis vaccines. Multiple vaccines were developed and tested; however, the heterogeneity of Leptospira species pose a challenge. As an effective approach, an epitope based vaccine shows quite a promising result. However, sufficient validation, testing and clinical trials are required. Conclusions: Developing an effective vaccine for leptospirosis remains a global health priority. While significant progress has been made in recent years, there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations. |
| first_indexed | 2024-09-25T03:40:59Z |
| format | Article |
| id | upm.eprints-108448 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:40:59Z |
| publishDate | 2023 |
| publisher | Medknow Publications |
| record_format | dspace |
| spelling | upm.eprints-1084482024-06-30T11:00:17Z http://psasir.upm.edu.my/id/eprint/108448/ Vaccine development for leptospirosis: a systematic review Surendran, Yocyny Nandikha, Mahalingam Amin-Nordin, Syafinaz Dhanda, Sandeep Kumar Mohd Ali, Mohamad Ridhuan Joseph, Narcisse Ms Objective: To assess the efficacy of various types of vaccines developed for leptospirosis. Methods: A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria are all Leptospira species regardless of any cluster (pathogenic, intermediate and non-pathogenic). This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine candidates. The studies on the effectiveness of outer membrane protein as vaccine candidates were also included. The articles obtained in the databases were imported into the WPS spreadsheet, and duplicate documents were removed manually. Results: A total of 24 studies were included in the review, which evaluated various types of leptospirosis vaccines. Multiple vaccines were developed and tested; however, the heterogeneity of Leptospira species pose a challenge. As an effective approach, an epitope based vaccine shows quite a promising result. However, sufficient validation, testing and clinical trials are required. Conclusions: Developing an effective vaccine for leptospirosis remains a global health priority. While significant progress has been made in recent years, there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations. Medknow Publications 2023 Article PeerReviewed Surendran, Yocyny and Nandikha, Mahalingam and Amin-Nordin, Syafinaz and Dhanda, Sandeep Kumar and Mohd Ali, Mohamad Ridhuan and Joseph, Narcisse Ms (2023) Vaccine development for leptospirosis: a systematic review. Asian Pacific Journal of Tropical Medicine, 16 (12). pp. 533-545. ISSN 1995-7645; ESSN: 2352-4146 https://journals.lww.com/10.4103/1995-7645.391775 10.4103/1995-7645.391775 |
| spellingShingle | Surendran, Yocyny Nandikha, Mahalingam Amin-Nordin, Syafinaz Dhanda, Sandeep Kumar Mohd Ali, Mohamad Ridhuan Joseph, Narcisse Ms Vaccine development for leptospirosis: a systematic review |
| title | Vaccine development for leptospirosis: a systematic review |
| title_full | Vaccine development for leptospirosis: a systematic review |
| title_fullStr | Vaccine development for leptospirosis: a systematic review |
| title_full_unstemmed | Vaccine development for leptospirosis: a systematic review |
| title_short | Vaccine development for leptospirosis: a systematic review |
| title_sort | vaccine development for leptospirosis a systematic review |
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