Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients
Background Obesity, particularly excessive body fat, is an established risk factor and substantial prognostic determinant in breast cancer. Recent studies suggested that diet-related inflammation plays a key role in obesity. This study aimed to determine the association between energy-adjusted dieta...
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| Format: | Article |
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Taylor & Francis
2023
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| _version_ | 1811137871507095552 |
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| author | Ng, Wai Han Abu Zaid, Zalina Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying |
| author_facet | Ng, Wai Han Abu Zaid, Zalina Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying |
| author_sort | Ng, Wai Han |
| collection | UPM |
| description | Background Obesity, particularly excessive body fat, is an established risk factor and substantial prognostic determinant in breast cancer. Recent studies suggested that diet-related inflammation plays a key role in obesity. This study aimed to determine the association between energy-adjusted dietary inflammatory index (E-DII) and body composition, particularly body fat percentage, among patients with newly diagnosed breast cancer. Materials and methods This cross-sectional study was conducted on 124 breast cancer outpatients within the first year of diagnosis and yet to commence oncological treatment. Body composition parameters [body weight, body mass index (BMI), body fat percentage, fat mass over fat-free mass ratio (FM/FFM), muscle mass, and visceral fat] were obtained using a bioelectrical impedance analyzer. Body fat percentage was categorized into two groups which were normal (<35%) and high (≥35%). The E-DII was calculated from the validated 165-items Food Frequency Questionnaire (FFQ) and categorized into three groups or tertiles. Multiple logistic regression analysis was used to determine the association between the E-DII and body fat percentage. Results Mean body weight, body fat percentage, FM/FFM, and visceral fat increased as E-DII increased from the lowest tertile (T1) to the most pro-inflammatory tertile (T3) (p for trend <0.05). E-DII was positively associated with body fat percentage (OR 2.952; 95% CI 1.154–7.556; p = 0.024) and remained significant after adjustment for cancer stage, age, physical activity, ethnicity, smoking history, and presence of comorbidities. Compared to T1, participants in T3 had a significantly lower consumption of fiber, vitamin A, beta-carotene, vitamin C, iron, thiamine, riboflavin, niacin, vitamin B6, folic acid, zinc, magnesium, and selenium, but a higher intake of total fat, saturated fat, and monounsaturated fatty acids. Conclusions A higher E-DII was associated with increased body fat percentage, suggesting the potential of advocating anti-inflammatory diet to combat obesity among newly diagnosed breast cancer patients. |
| first_indexed | 2024-09-25T03:41:11Z |
| format | Article |
| id | upm.eprints-108943 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:41:11Z |
| publishDate | 2023 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-1089432024-05-11T15:02:16Z http://psasir.upm.edu.my/id/eprint/108943/ Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients Ng, Wai Han Abu Zaid, Zalina Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying Background Obesity, particularly excessive body fat, is an established risk factor and substantial prognostic determinant in breast cancer. Recent studies suggested that diet-related inflammation plays a key role in obesity. This study aimed to determine the association between energy-adjusted dietary inflammatory index (E-DII) and body composition, particularly body fat percentage, among patients with newly diagnosed breast cancer. Materials and methods This cross-sectional study was conducted on 124 breast cancer outpatients within the first year of diagnosis and yet to commence oncological treatment. Body composition parameters [body weight, body mass index (BMI), body fat percentage, fat mass over fat-free mass ratio (FM/FFM), muscle mass, and visceral fat] were obtained using a bioelectrical impedance analyzer. Body fat percentage was categorized into two groups which were normal (<35%) and high (≥35%). The E-DII was calculated from the validated 165-items Food Frequency Questionnaire (FFQ) and categorized into three groups or tertiles. Multiple logistic regression analysis was used to determine the association between the E-DII and body fat percentage. Results Mean body weight, body fat percentage, FM/FFM, and visceral fat increased as E-DII increased from the lowest tertile (T1) to the most pro-inflammatory tertile (T3) (p for trend <0.05). E-DII was positively associated with body fat percentage (OR 2.952; 95% CI 1.154–7.556; p = 0.024) and remained significant after adjustment for cancer stage, age, physical activity, ethnicity, smoking history, and presence of comorbidities. Compared to T1, participants in T3 had a significantly lower consumption of fiber, vitamin A, beta-carotene, vitamin C, iron, thiamine, riboflavin, niacin, vitamin B6, folic acid, zinc, magnesium, and selenium, but a higher intake of total fat, saturated fat, and monounsaturated fatty acids. Conclusions A higher E-DII was associated with increased body fat percentage, suggesting the potential of advocating anti-inflammatory diet to combat obesity among newly diagnosed breast cancer patients. Taylor & Francis 2023 Article PeerReviewed Ng, Wai Han and Abu Zaid, Zalina and Mohd Yusof, Barakatun Nisak and Amin Nordin, Syafinaz and Lim, Poh Ying (2023) Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients. Annals of Medicine, 55 (2). art. no. 2303399. pp. 1-11. ISSN 0785-3890 https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2303399 10.1080/07853890.2024.2303399 |
| spellingShingle | Ng, Wai Han Abu Zaid, Zalina Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
| title | Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
| title_full | Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
| title_fullStr | Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
| title_full_unstemmed | Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
| title_short | Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
| title_sort | association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients |
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