The effect of unrefined sugar on inflammation: a systematic review of intervention studies
Background: It is well established that unrefined sugarcane products have antioxidant activity due to phytochemicals, polyphenols, and total antioxidant capacity, which may decrease inflammation and oxidative stress. Therefore, we conducted a systematic review to evaluate the association of unrefi...
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| Format: | Article |
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Medknow Publications
2023
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| _version_ | 1825939718350569472 |
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| author | Ebadi, Samarghand Azlan, Azrina |
| author_facet | Ebadi, Samarghand Azlan, Azrina |
| author_sort | Ebadi, Samarghand |
| collection | UPM |
| description | Background: It is well established that unrefined sugarcane products have antioxidant activity due to
phytochemicals, polyphenols, and total antioxidant capacity, which may decrease inflammation and
oxidative stress. Therefore, we conducted a systematic review to evaluate the association of unrefined
sugar consumption with inflammatory biomarkers. Methods: Google Scholar, ScienceDirect, Scopus,
Cochrane Library, and ProQuest databases were searched up to December 2021 for studies that report
the effect of unrefined sugar on inflammation according to inflammatory cytokines, chemokine, and
adhesion molecules as outcome measures. Results: Thirty‑six studies were evaluated. Across all
research, five studies (two in vitro and three animal studies) reported the effect of unrefined sugar
on levels of cytokines, including IL‑6, TNF‑α, IL‑10, IL‑1β, and IFN‑γ. Additionally, the quality
of the studies was assessed for risk of bias. Conclusions: it is possible to affirm that unrefined
sugarcane products, including jaggery, may have a protective effect on inflammation via regulating
some of the inflammatory pathways and a favorable impact on cytokines secretion according to the
results of in vitro and animal model studies. However, since the findings are still insufficient, more
scientific research, especially well‑designed human trials, is highly recommended to conclude the
outcomes confidently. Human data may encourage industries and the public to replace purified sugar
with unrefined sugarcane in sugar‑based food and for further health‑care policy decisions. |
| first_indexed | 2024-12-09T02:21:25Z |
| format | Article |
| id | upm.eprints-109139 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-12-09T02:21:25Z |
| publishDate | 2023 |
| publisher | Medknow Publications |
| record_format | dspace |
| spelling | upm.eprints-1091392024-10-14T07:30:03Z http://psasir.upm.edu.my/id/eprint/109139/ The effect of unrefined sugar on inflammation: a systematic review of intervention studies Ebadi, Samarghand Azlan, Azrina Background: It is well established that unrefined sugarcane products have antioxidant activity due to phytochemicals, polyphenols, and total antioxidant capacity, which may decrease inflammation and oxidative stress. Therefore, we conducted a systematic review to evaluate the association of unrefined sugar consumption with inflammatory biomarkers. Methods: Google Scholar, ScienceDirect, Scopus, Cochrane Library, and ProQuest databases were searched up to December 2021 for studies that report the effect of unrefined sugar on inflammation according to inflammatory cytokines, chemokine, and adhesion molecules as outcome measures. Results: Thirty‑six studies were evaluated. Across all research, five studies (two in vitro and three animal studies) reported the effect of unrefined sugar on levels of cytokines, including IL‑6, TNF‑α, IL‑10, IL‑1β, and IFN‑γ. Additionally, the quality of the studies was assessed for risk of bias. Conclusions: it is possible to affirm that unrefined sugarcane products, including jaggery, may have a protective effect on inflammation via regulating some of the inflammatory pathways and a favorable impact on cytokines secretion according to the results of in vitro and animal model studies. However, since the findings are still insufficient, more scientific research, especially well‑designed human trials, is highly recommended to conclude the outcomes confidently. Human data may encourage industries and the public to replace purified sugar with unrefined sugarcane in sugar‑based food and for further health‑care policy decisions. Medknow Publications 2023-10 Article PeerReviewed Ebadi, Samarghand and Azlan, Azrina (2023) The effect of unrefined sugar on inflammation: a systematic review of intervention studies. International Journal of Preventive Medicine, 14 (1). art. no. 121. pp. 1-12. ISSN 2008-7802; ESSN: 2008-8213 https://journals.lww.com/ijom/fulltext/2023/10300/the_effect_of_unrefined_sugar_on_inflammation__a.4.aspx 10.4103/ijpvm.ijpvm_318_22 |
| spellingShingle | Ebadi, Samarghand Azlan, Azrina The effect of unrefined sugar on inflammation: a systematic review of intervention studies |
| title | The effect of unrefined sugar on inflammation: a systematic review of intervention studies |
| title_full | The effect of unrefined sugar on inflammation: a systematic review of intervention studies |
| title_fullStr | The effect of unrefined sugar on inflammation: a systematic review of intervention studies |
| title_full_unstemmed | The effect of unrefined sugar on inflammation: a systematic review of intervention studies |
| title_short | The effect of unrefined sugar on inflammation: a systematic review of intervention studies |
| title_sort | effect of unrefined sugar on inflammation a systematic review of intervention studies |
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