| Summary: | This study describes the synthesis, characterization, and biological activities of halogenated xanthone, 3-O
substituted xanthone, and prenylated xanthone derivatives. The molecular structures of these compounds were
identified using 1
H NMR, 13C NMR, 2D NMR, FTIR and DIMS. All synthesized compounds were evaluated against
two cancer cell lines: breast adenocarcinoma MCF-7 and MDA-MB-231 by application of the MTT assay. With this
approach, xanthones 9 and 13 were identified as putative aromatase activating agents through the inhibition of
interactions with MCF-7 and MDA-MB-231. The selected compounds, 9 and 13, were further examined for
toxicity against the African Green Monkey Kidney cell (VERO) and Non-tumorigenic Lung Epithelial cell lines
(BEAS-2B). In addition, in-silico docking studies were conducted to estimate the binding poses and residues
implicated in probable MCF-7 and MDA-MB-231 interactions.
|
|---|