One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors
This study describes the synthesis, characterization, and biological activities of halogenated xanthone, 3-O substituted xanthone, and prenylated xanthone derivatives. The molecular structures of these compounds were identified using 1 H NMR, 13C NMR, 2D NMR, FTIR and DIMS. All synthesized compou...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier BV
2023
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| _version_ | 1825939740513271808 |
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| author | Ramakrishnan, Shurutishria Mad Nasir, Nadiah Stanslas, Johnson Faisal Hamdi, Amir Imran Mohammad Latif, Muhammad Alif Baharuddin, Fatin Farhana |
| author_facet | Ramakrishnan, Shurutishria Mad Nasir, Nadiah Stanslas, Johnson Faisal Hamdi, Amir Imran Mohammad Latif, Muhammad Alif Baharuddin, Fatin Farhana |
| author_sort | Ramakrishnan, Shurutishria |
| collection | UPM |
| description | This study describes the synthesis, characterization, and biological activities of halogenated xanthone, 3-O
substituted xanthone, and prenylated xanthone derivatives. The molecular structures of these compounds were
identified using 1
H NMR, 13C NMR, 2D NMR, FTIR and DIMS. All synthesized compounds were evaluated against
two cancer cell lines: breast adenocarcinoma MCF-7 and MDA-MB-231 by application of the MTT assay. With this
approach, xanthones 9 and 13 were identified as putative aromatase activating agents through the inhibition of
interactions with MCF-7 and MDA-MB-231. The selected compounds, 9 and 13, were further examined for
toxicity against the African Green Monkey Kidney cell (VERO) and Non-tumorigenic Lung Epithelial cell lines
(BEAS-2B). In addition, in-silico docking studies were conducted to estimate the binding poses and residues
implicated in probable MCF-7 and MDA-MB-231 interactions. |
| first_indexed | 2024-09-25T03:41:47Z |
| format | Article |
| id | upm.eprints-109265 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:41:47Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | upm.eprints-1092652024-08-16T07:57:09Z http://psasir.upm.edu.my/id/eprint/109265/ One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors Ramakrishnan, Shurutishria Mad Nasir, Nadiah Stanslas, Johnson Faisal Hamdi, Amir Imran Mohammad Latif, Muhammad Alif Baharuddin, Fatin Farhana This study describes the synthesis, characterization, and biological activities of halogenated xanthone, 3-O substituted xanthone, and prenylated xanthone derivatives. The molecular structures of these compounds were identified using 1 H NMR, 13C NMR, 2D NMR, FTIR and DIMS. All synthesized compounds were evaluated against two cancer cell lines: breast adenocarcinoma MCF-7 and MDA-MB-231 by application of the MTT assay. With this approach, xanthones 9 and 13 were identified as putative aromatase activating agents through the inhibition of interactions with MCF-7 and MDA-MB-231. The selected compounds, 9 and 13, were further examined for toxicity against the African Green Monkey Kidney cell (VERO) and Non-tumorigenic Lung Epithelial cell lines (BEAS-2B). In addition, in-silico docking studies were conducted to estimate the binding poses and residues implicated in probable MCF-7 and MDA-MB-231 interactions. Elsevier BV 2023-01 Article PeerReviewed Ramakrishnan, Shurutishria and Mad Nasir, Nadiah and Stanslas, Johnson and Faisal Hamdi, Amir Imran and Mohammad Latif, Muhammad Alif and Baharuddin, Fatin Farhana (2023) One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors. Results in Chemistry, 5. art. no. 100789. pp. 1-11. ISSN 2211-7156 https://linkinghub.elsevier.com/retrieve/pii/S2211715623000280 10.1016/j.rechem.2023.100789 |
| spellingShingle | Ramakrishnan, Shurutishria Mad Nasir, Nadiah Stanslas, Johnson Faisal Hamdi, Amir Imran Mohammad Latif, Muhammad Alif Baharuddin, Fatin Farhana One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors |
| title | One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors |
| title_full | One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors |
| title_fullStr | One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors |
| title_full_unstemmed | One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors |
| title_short | One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors |
| title_sort | one pot two component synthesis of halogenated xanthone 3 o substituted xanthone and prenylated xanthone derivatives as aromatase inhibitors |
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