Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function
Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation. A few articles have previous...
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| Format: | Article |
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Elsevier
2023
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| _version_ | 1811137938629591040 |
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| author | Ng, Chin Theng Fong, Lai Yen Abdullah, Muhammad Nazrul Hakim |
| author_facet | Ng, Chin Theng Fong, Lai Yen Abdullah, Muhammad Nazrul Hakim |
| author_sort | Ng, Chin Theng |
| collection | UPM |
| description | Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation. A few articles have previously reviewed the effects of IFN-γ in the regulation of barrier permeability, but none of these articles focuses on barrier function of endothelial cells. This review aims to discuss the regulatory mechanisms of IFN-γ on endothelial barrier function and its underlying signaling pathways. Articles were retrieved from electronic databases such as PubMed and Google Scholar using keywords “Interferon-gamma”, “endothelial cells”, “barrier function”, and “signaling pathway”. The articles published between 2000 and 2022 that are related to the aforementioned topics were selected. A few journals published beyond this period were also included due to limited information available. The results showed that IFN-γ modulates endothelial barrier function, mainly involves small GTPases, STAT1-dependent pathway, p38 MAPK and nitric oxide. In conclusion, more in depth cellular and molecular studies are needed to elucidate the pathways of IFN-γ in the regulation of endothelial barrier function. |
| first_indexed | 2024-09-25T03:42:15Z |
| format | Article |
| id | upm.eprints-109436 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:42:15Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-1094362024-08-05T02:20:31Z http://psasir.upm.edu.my/id/eprint/109436/ Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function Ng, Chin Theng Fong, Lai Yen Abdullah, Muhammad Nazrul Hakim Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation. A few articles have previously reviewed the effects of IFN-γ in the regulation of barrier permeability, but none of these articles focuses on barrier function of endothelial cells. This review aims to discuss the regulatory mechanisms of IFN-γ on endothelial barrier function and its underlying signaling pathways. Articles were retrieved from electronic databases such as PubMed and Google Scholar using keywords “Interferon-gamma”, “endothelial cells”, “barrier function”, and “signaling pathway”. The articles published between 2000 and 2022 that are related to the aforementioned topics were selected. A few journals published beyond this period were also included due to limited information available. The results showed that IFN-γ modulates endothelial barrier function, mainly involves small GTPases, STAT1-dependent pathway, p38 MAPK and nitric oxide. In conclusion, more in depth cellular and molecular studies are needed to elucidate the pathways of IFN-γ in the regulation of endothelial barrier function. Elsevier 2023-06 Article PeerReviewed Ng, Chin Theng and Fong, Lai Yen and Abdullah, Muhammad Nazrul Hakim (2023) Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function. Cytokine, 166. art. no. 156208. pp. 1-7. ISSN 1043-4666 https://www.sciencedirect.com/science/article/pii/S1043466623000868?via%3Dihub 10.1016/j.cyto.2023.156208 |
| spellingShingle | Ng, Chin Theng Fong, Lai Yen Abdullah, Muhammad Nazrul Hakim Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
| title | Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
| title_full | Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
| title_fullStr | Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
| title_full_unstemmed | Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
| title_short | Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
| title_sort | interferon gamma ifn γ reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function |
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