Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions
Non-invasive prenatal testing was first discovered in 1988; it was primarily thought to be able to detect common aneuploidies, such as Patau syndrome (T13), Edward Syndrome (T18), and Down syndrome (T21). It comprises a simple technique involving the analysis of cell-free foetal DNA (cffDNA) obtaine...
| 主要な著者: | , , , , , , |
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| フォーマット: | 論文 |
| 出版事項: |
Multidisciplinary Digital Publishing Institute
2023
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| _version_ | 1825939824382574592 |
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| author | Jayashankar, Siva Shantini Nasaruddin, Muhammad Luqman Hassan, Muhammad Faiz Dasrilsyah, Rima Anggrena Shafiee, Mohamad Nasir Ismail, Noor Akmal Shareela Alias, Ekram |
| author_facet | Jayashankar, Siva Shantini Nasaruddin, Muhammad Luqman Hassan, Muhammad Faiz Dasrilsyah, Rima Anggrena Shafiee, Mohamad Nasir Ismail, Noor Akmal Shareela Alias, Ekram |
| author_sort | Jayashankar, Siva Shantini |
| collection | UPM |
| description | Non-invasive prenatal testing was first discovered in 1988; it was primarily thought to be able to detect common aneuploidies, such as Patau syndrome (T13), Edward Syndrome (T18), and Down syndrome (T21). It comprises a simple technique involving the analysis of cell-free foetal DNA (cffDNA) obtained through maternal serum, using advances in next-generation sequencing. NIPT has shown promise as a simple and low-risk screening test, leading various governments and private organizations worldwide to dedicate significant resources towards its integration into national healthcare initiatives as well as the formation of consortia and research studies aimed at standardizing its implementation. This article aims to review the reliability of NIPT while discussing the current challenges prevalent among different communities worldwide. |
| first_indexed | 2024-09-25T03:42:39Z |
| format | Article |
| id | upm.eprints-110169 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-09-25T03:42:39Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-1101692024-09-04T04:17:47Z http://psasir.upm.edu.my/id/eprint/110169/ Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions Jayashankar, Siva Shantini Nasaruddin, Muhammad Luqman Hassan, Muhammad Faiz Dasrilsyah, Rima Anggrena Shafiee, Mohamad Nasir Ismail, Noor Akmal Shareela Alias, Ekram Non-invasive prenatal testing was first discovered in 1988; it was primarily thought to be able to detect common aneuploidies, such as Patau syndrome (T13), Edward Syndrome (T18), and Down syndrome (T21). It comprises a simple technique involving the analysis of cell-free foetal DNA (cffDNA) obtained through maternal serum, using advances in next-generation sequencing. NIPT has shown promise as a simple and low-risk screening test, leading various governments and private organizations worldwide to dedicate significant resources towards its integration into national healthcare initiatives as well as the formation of consortia and research studies aimed at standardizing its implementation. This article aims to review the reliability of NIPT while discussing the current challenges prevalent among different communities worldwide. Multidisciplinary Digital Publishing Institute 2023 Article PeerReviewed Jayashankar, Siva Shantini and Nasaruddin, Muhammad Luqman and Hassan, Muhammad Faiz and Dasrilsyah, Rima Anggrena and Shafiee, Mohamad Nasir and Ismail, Noor Akmal Shareela and Alias, Ekram (2023) Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions. Diagnostics, 13 (15). art. no. 2570. pp. 1-21. ISSN 2075-4418 https://www.mdpi.com/2075-4418/13/15/2570 10.3390/diagnostics13152570 |
| spellingShingle | Jayashankar, Siva Shantini Nasaruddin, Muhammad Luqman Hassan, Muhammad Faiz Dasrilsyah, Rima Anggrena Shafiee, Mohamad Nasir Ismail, Noor Akmal Shareela Alias, Ekram Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions |
| title | Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions |
| title_full | Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions |
| title_fullStr | Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions |
| title_full_unstemmed | Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions |
| title_short | Non-invasive prenatal testing (NIPT): reliability, challenges, and future directions |
| title_sort | non invasive prenatal testing nipt reliability challenges and future directions |
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