Impaired neural stress resistance and loss of REST in bipolar disorder

Impaired neural stress resistance and loss of REST in bipolar disorder

Neurodevelopmental changes and impaired stress resistance have been implicated in the pathogenesis of bipolar disorder (BD), but the underlying regulatory mechanisms are unresolved. Here we describe a human cerebral organoid model of BD that exhibits altered neural development, elevated neural netwo...

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Bibliographic Details
Main Authors: Meyer, Katharina, Ling, King-Hwa, Yeo, Pei-Ling, Spathopoulou, Angeliki, Drake, Derek, Choi, Jaejoon, Aron, Liviu, Garcia-Corral, Mariana, Ko, Tak, Lee, Eunjung Alice, Tam, Jenny M., Perlis, Roy H., Church, George M., Tsai, Li-Huei, Yankner, Bruce A.
Format: Article
Published: Springer Nature 2023

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