Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
Background & Aims: Accumulating evidence showed that inflammation contributes markedly to cancer progression, with C-reactive protein (CRP) being one of the lengthily studied inflammation marker. For breast cancer (BCa), pre-treatment elevated CRP upon diagnosis was linked with increased mortal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/111456/1/PUBLISHED.pdf |
| _version_ | 1811138055527989248 |
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| author | Abu Zaid, Zalina Ng, Wai Han Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying |
| author_facet | Abu Zaid, Zalina Ng, Wai Han Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying |
| author_sort | Abu Zaid, Zalina |
| collection | UPM |
| description | Background & Aims: Accumulating evidence showed that inflammation contributes markedly to cancer progression,
with C-reactive protein (CRP) being one of the lengthily studied inflammation marker. For breast cancer (BCa), pre-treatment elevated CRP upon diagnosis was linked with increased mortality. This study aimed to identify factors predictive of elevated CRP in pre-treatment BCa population that can serve as potential therapeutic targets to reduce inflammation.Methods: This is a cross-sectional study using multiple logistic regression to identify predictors of elevated CRP among pre-treatment, newly diagnosed BCa patients. Studied variables were socio-demographic and medical
characteristics, anthropometric measurements [body weight, Body Mass Index, body fat percentage, fat mass/fat free mass ratio, muscle mass, visceral fat], biochemical parameters [albumin, hemoglobin, white blood cell (WBC), neutrophil, lymphocyte], energy-adjusted Dietary Inflammatory Index, handgrip strength (HGS), scored Patient Generated-Subjective Global Assessment, physical activity level and perceived stress scale (PSS). Results: A total of 105 participants took part in this study. Significant predictors of elevated CRP were body fat percentage (OR 1.222; 95 % CI 1.099–1.358; p < 0.001), PSS (OR 1.120; 95 % CI 1.026–1.223; p = 0.011), low vs normal HGS (OR 41.928; 95 % CI 2.155–815.728; p = 0.014), albumin (OR 0.779; 95 % CI 0.632–0.960; p = 0.019), and WBC (OR 1.418; 95% CI 1.024–1.963; p = 0.036). Conclusion: Overall, predictors of elevated CRP in pre-treatment, newly diagnosed BCa population were body fat percentage, PSS, HGS category, albumin and WBC. |
| first_indexed | 2024-09-25T03:44:07Z |
| format | Article |
| id | upm.eprints-111456 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-09-25T03:44:07Z |
| publishDate | 2024 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | upm.eprints-1114562024-07-14T08:28:42Z http://psasir.upm.edu.my/id/eprint/111456/ Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study Abu Zaid, Zalina Ng, Wai Han Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying Background & Aims: Accumulating evidence showed that inflammation contributes markedly to cancer progression, with C-reactive protein (CRP) being one of the lengthily studied inflammation marker. For breast cancer (BCa), pre-treatment elevated CRP upon diagnosis was linked with increased mortality. This study aimed to identify factors predictive of elevated CRP in pre-treatment BCa population that can serve as potential therapeutic targets to reduce inflammation.Methods: This is a cross-sectional study using multiple logistic regression to identify predictors of elevated CRP among pre-treatment, newly diagnosed BCa patients. Studied variables were socio-demographic and medical characteristics, anthropometric measurements [body weight, Body Mass Index, body fat percentage, fat mass/fat free mass ratio, muscle mass, visceral fat], biochemical parameters [albumin, hemoglobin, white blood cell (WBC), neutrophil, lymphocyte], energy-adjusted Dietary Inflammatory Index, handgrip strength (HGS), scored Patient Generated-Subjective Global Assessment, physical activity level and perceived stress scale (PSS). Results: A total of 105 participants took part in this study. Significant predictors of elevated CRP were body fat percentage (OR 1.222; 95 % CI 1.099–1.358; p < 0.001), PSS (OR 1.120; 95 % CI 1.026–1.223; p = 0.011), low vs normal HGS (OR 41.928; 95 % CI 2.155–815.728; p = 0.014), albumin (OR 0.779; 95 % CI 0.632–0.960; p = 0.019), and WBC (OR 1.418; 95% CI 1.024–1.963; p = 0.036). Conclusion: Overall, predictors of elevated CRP in pre-treatment, newly diagnosed BCa population were body fat percentage, PSS, HGS category, albumin and WBC. Elsevier Ltd 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111456/1/PUBLISHED.pdf Abu Zaid, Zalina and Ng, Wai Han and Mohd Yusof, Barakatun Nisak and Amin Nordin, Syafinaz and Lim, Poh Ying (2024) Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study. Cancer Treatment and Research Communications, 39. art. no. 100813. pp. 1-7. ISSN 2468-2942 https://www.sciencedirect.com/science/article/pii/S246829422400025X 10.1016/j.ctarc.2024.100813 |
| spellingShingle | Abu Zaid, Zalina Ng, Wai Han Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study |
| title | Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study |
| title_full | Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study |
| title_fullStr | Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study |
| title_full_unstemmed | Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study |
| title_short | Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study |
| title_sort | predictors of elevated c reactive protein among pre treatment newly diagnosed breast cancer patients a cross sectional study |
| url | http://psasir.upm.edu.my/id/eprint/111456/1/PUBLISHED.pdf |
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