Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice
High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SC), one of the main nutritional and functional components of Torreya grandis seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty ac...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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Royal Society of Chemistry
2024
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| _version_ | 1825940206292828160 |
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| author | Yao, Shiwei Lu, Hongling Zhou, Tianhuan Jiang, Qihong Jiang, Chenkai Hu, Wenjun Li, Mingqian Tan, Chin Ping Feng, Yongcai Du, Qun Shen, Guoxin Xiang, Xingwei Chen, Lin |
| author_facet | Yao, Shiwei Lu, Hongling Zhou, Tianhuan Jiang, Qihong Jiang, Chenkai Hu, Wenjun Li, Mingqian Tan, Chin Ping Feng, Yongcai Du, Qun Shen, Guoxin Xiang, Xingwei Chen, Lin |
| author_sort | Yao, Shiwei |
| collection | UPM |
| description | High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SC), one of the main nutritional and functional components of Torreya grandis seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty acid (Δ5-UPIFA) that has been claimed to counteract such disorders owing to some of its physiological effects. However, the role of SC in ameliorating bone metabolism disorders due to HFD remains unclear. In the present investigation, we observed that SC modulates the OPG/RANKL/RANK signaling pathway by modifying the lipid metabolic state and decreasing inflammation in mice. In turn, it could balance bone resorption and formation as well as calcium and phosphorus levels, enhance bone strength and bone mineral density (BMD), and improve its microstructure. In addition, SC could inhibit fat vacuoles in bone, reverse the phenomenon of reduced numbers and poor continuity of bone trabeculae, and promote orderly arrangement of collagen fibers and cartilage repair. This study provides some theoretical basis for SC as a dietary intervention agent to enhance bone nutrition. © 2024 The Royal Society of Chemistry. |
| first_indexed | 2024-12-09T02:24:40Z |
| format | Article |
| id | upm.eprints-112845 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-12-09T02:24:40Z |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | upm.eprints-1128452024-11-06T04:02:25Z http://psasir.upm.edu.my/id/eprint/112845/ Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice Yao, Shiwei Lu, Hongling Zhou, Tianhuan Jiang, Qihong Jiang, Chenkai Hu, Wenjun Li, Mingqian Tan, Chin Ping Feng, Yongcai Du, Qun Shen, Guoxin Xiang, Xingwei Chen, Lin High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SC), one of the main nutritional and functional components of Torreya grandis seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty acid (Δ5-UPIFA) that has been claimed to counteract such disorders owing to some of its physiological effects. However, the role of SC in ameliorating bone metabolism disorders due to HFD remains unclear. In the present investigation, we observed that SC modulates the OPG/RANKL/RANK signaling pathway by modifying the lipid metabolic state and decreasing inflammation in mice. In turn, it could balance bone resorption and formation as well as calcium and phosphorus levels, enhance bone strength and bone mineral density (BMD), and improve its microstructure. In addition, SC could inhibit fat vacuoles in bone, reverse the phenomenon of reduced numbers and poor continuity of bone trabeculae, and promote orderly arrangement of collagen fibers and cartilage repair. This study provides some theoretical basis for SC as a dietary intervention agent to enhance bone nutrition. © 2024 The Royal Society of Chemistry. Royal Society of Chemistry 2024 Article PeerReviewed Yao, Shiwei and Lu, Hongling and Zhou, Tianhuan and Jiang, Qihong and Jiang, Chenkai and Hu, Wenjun and Li, Mingqian and Tan, Chin Ping and Feng, Yongcai and Du, Qun and Shen, Guoxin and Xiang, Xingwei and Chen, Lin (2024) Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice. Food and Function, 15 (8). pp. 4490-4502. ISSN 2042-6496; eISSN: 2042-650X https://pubs.rsc.org/en/content/articlelanding/2024/fo/d3fo04527g 10.1039/d3fo04527g |
| spellingShingle | Yao, Shiwei Lu, Hongling Zhou, Tianhuan Jiang, Qihong Jiang, Chenkai Hu, Wenjun Li, Mingqian Tan, Chin Ping Feng, Yongcai Du, Qun Shen, Guoxin Xiang, Xingwei Chen, Lin Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice |
| title | Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice |
| title_full | Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice |
| title_fullStr | Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice |
| title_full_unstemmed | Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice |
| title_short | Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice |
| title_sort | sciadonic acid attenuates high fat diet induced bone metabolism disorders in mice |
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