Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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The Society for Free Radical Research Japan
1993
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114031/1/114031.pdf |
| _version_ | 1817928009936535552 |
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| author | Rahmat, Asmah Wan Ngah, Wan Zurinah Jarien, Zanariah Ismail, Rosnani Marzuki, Alini Abdul Kadir, Khalid Shamaan, Nor Aripin |
| author_facet | Rahmat, Asmah Wan Ngah, Wan Zurinah Jarien, Zanariah Ismail, Rosnani Marzuki, Alini Abdul Kadir, Khalid Shamaan, Nor Aripin |
| author_sort | Rahmat, Asmah |
| collection | UPM |
| description | The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, and blood glutathione (GSH). Rats treated with DEN/AAF had significantly elevated plasma and microsomal GGT, plasma ALP activities, and blood GSH levels compared with the normal controls (Ρ<0.05). Supplementation with vitamin E of normal controls did not affect the enzyme activities or blood GSH. in rats treated with DEN/AAF, vitamin E supplementation attenuated GGT and ALP activitiesand blood GSH levels. the optimum dose required for highest attenuation of the tumor marker enzyme activities was 34 mg/kg diet for α-tocopherol and 30 mg/kg diet for y-tocotrienol. Higher doses of the vitamin did not show further attenuation in the level of the tumor marker enzyme activities. |
| first_indexed | 2024-12-09T02:27:32Z |
| format | Article |
| id | upm.eprints-114031 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-12-09T02:27:32Z |
| publishDate | 1993 |
| publisher | The Society for Free Radical Research Japan |
| record_format | dspace |
| spelling | upm.eprints-1140312024-12-08T08:04:24Z http://psasir.upm.edu.my/id/eprint/114031/ Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat Rahmat, Asmah Wan Ngah, Wan Zurinah Jarien, Zanariah Ismail, Rosnani Marzuki, Alini Abdul Kadir, Khalid Shamaan, Nor Aripin The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, and blood glutathione (GSH). Rats treated with DEN/AAF had significantly elevated plasma and microsomal GGT, plasma ALP activities, and blood GSH levels compared with the normal controls (Ρ<0.05). Supplementation with vitamin E of normal controls did not affect the enzyme activities or blood GSH. in rats treated with DEN/AAF, vitamin E supplementation attenuated GGT and ALP activitiesand blood GSH levels. the optimum dose required for highest attenuation of the tumor marker enzyme activities was 34 mg/kg diet for α-tocopherol and 30 mg/kg diet for y-tocotrienol. Higher doses of the vitamin did not show further attenuation in the level of the tumor marker enzyme activities. The Society for Free Radical Research Japan 1993 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114031/1/114031.pdf Rahmat, Asmah and Wan Ngah, Wan Zurinah and Jarien, Zanariah and Ismail, Rosnani and Marzuki, Alini and Abdul Kadir, Khalid and Shamaan, Nor Aripin (1993) Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat. Journal of Clinical Biochemistry and Nutrition, 15 (3). pp. 195-202. ISSN 0912-0009; eISSN: 1880-5086 https://www.jstage.jst.go.jp/article/jcbn1986/15/3/15_3_195/_article 10.3164/jcbn.15.195 |
| spellingShingle | Rahmat, Asmah Wan Ngah, Wan Zurinah Jarien, Zanariah Ismail, Rosnani Marzuki, Alini Abdul Kadir, Khalid Shamaan, Nor Aripin Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| title | Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| title_full | Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| title_fullStr | Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| title_full_unstemmed | Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| title_short | Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| title_sort | effect of γ tocotrienol and α tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat |
| url | http://psasir.upm.edu.my/id/eprint/114031/1/114031.pdf |
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