Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study
Walking pace is a simple and functional form of exercise and a strong predictor of health, but little is known about its causal association with rheumatoid arthritis. This study aimed to investigate the causal effect of WP on the developing RA using Mendelian randomization analysis. The genetic vari...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Research
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114381/1/114381.pdf |
| _version_ | 1824452397937721344 |
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| author | Zhang, Qin Huang, Xiaoxiong Zhang, Yazhong Chao, Zhujun Zhou, Ruoran Abd Hamid, Roslida Zhen, Yunfang Li, Yusheng Huang, Cheng Xu, Wu Lin, Jun |
| author_facet | Zhang, Qin Huang, Xiaoxiong Zhang, Yazhong Chao, Zhujun Zhou, Ruoran Abd Hamid, Roslida Zhen, Yunfang Li, Yusheng Huang, Cheng Xu, Wu Lin, Jun |
| author_sort | Zhang, Qin |
| collection | UPM |
| description | Walking pace is a simple and functional form of exercise and a strong predictor of health, but little is known about its causal association with rheumatoid arthritis. This study aimed to investigate the causal effect of WP on the developing RA using Mendelian randomization analysis. The genetic variation associated with WP was selected as an instrumental variable from the latest genome-wide association studies. Summary-level data for the outcomes were obtained from the corresponding GWAS. The inverse-variance weighted method was used as the primary MR analysis. The results were further tested using a multivariable MR approach based on Bayesian model averaging. Confounders (BMI, SMK, HBP, TD) with close associations with RA were included in the analysis. An observational study with individual data from UK Biobank was performed to reinforce our findings. The MR results indicated the significant inverse associations of WP with the risk of RA (odds ratio (OR), 0.31; 95% confidence interval (CI), 0.15, 0.62; p = 1.05 × 10 −3). After adjusting for the risk factors, the associations for WP and RA did not change substantially. Observational study results demonstrated the same effect of WP on reducing the risk of RA. The Mendelian randomization analysis and observational study provide evidence suggesting that walking pace is a protective factor for rheumatoid arthritis. Given its simple measurement, walking pace may be a pragmatic target for interventions. |
| first_indexed | 2025-02-19T02:49:53Z |
| format | Article |
| id | upm.eprints-114381 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:49:53Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | upm.eprints-1143812025-01-20T00:51:02Z http://psasir.upm.edu.my/id/eprint/114381/ Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study Zhang, Qin Huang, Xiaoxiong Zhang, Yazhong Chao, Zhujun Zhou, Ruoran Abd Hamid, Roslida Zhen, Yunfang Li, Yusheng Huang, Cheng Xu, Wu Lin, Jun Walking pace is a simple and functional form of exercise and a strong predictor of health, but little is known about its causal association with rheumatoid arthritis. This study aimed to investigate the causal effect of WP on the developing RA using Mendelian randomization analysis. The genetic variation associated with WP was selected as an instrumental variable from the latest genome-wide association studies. Summary-level data for the outcomes were obtained from the corresponding GWAS. The inverse-variance weighted method was used as the primary MR analysis. The results were further tested using a multivariable MR approach based on Bayesian model averaging. Confounders (BMI, SMK, HBP, TD) with close associations with RA were included in the analysis. An observational study with individual data from UK Biobank was performed to reinforce our findings. The MR results indicated the significant inverse associations of WP with the risk of RA (odds ratio (OR), 0.31; 95% confidence interval (CI), 0.15, 0.62; p = 1.05 × 10 −3). After adjusting for the risk factors, the associations for WP and RA did not change substantially. Observational study results demonstrated the same effect of WP on reducing the risk of RA. The Mendelian randomization analysis and observational study provide evidence suggesting that walking pace is a protective factor for rheumatoid arthritis. Given its simple measurement, walking pace may be a pragmatic target for interventions. Nature Research 2024-10 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114381/1/114381.pdf Zhang, Qin and Huang, Xiaoxiong and Zhang, Yazhong and Chao, Zhujun and Zhou, Ruoran and Abd Hamid, Roslida and Zhen, Yunfang and Li, Yusheng and Huang, Cheng and Xu, Wu and Lin, Jun (2024) Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study. Scientific Reports, 14 (1). art. no. 24886. pp. 1-10. ISSN 2045-2322 https://www.nature.com/articles/s41598-024-76666-6 10.1038/s41598-024-76666-6 |
| spellingShingle | Zhang, Qin Huang, Xiaoxiong Zhang, Yazhong Chao, Zhujun Zhou, Ruoran Abd Hamid, Roslida Zhen, Yunfang Li, Yusheng Huang, Cheng Xu, Wu Lin, Jun Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study |
| title | Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study |
| title_full | Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study |
| title_fullStr | Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study |
| title_full_unstemmed | Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study |
| title_short | Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study |
| title_sort | walking pace is a protective factor for rheumatoid arthritis a mendelian randomization study |
| url | http://psasir.upm.edu.my/id/eprint/114381/1/114381.pdf |
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