Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin
The widespread presence of microplastics in the environment has raised significant concerns regarding their potential impact on human and animal health. Among various microplastic types, polyethylene microplastics (PE-MPs) are particularly prevalent due to the extensive use in packaging and consumer...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Research
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114602/1/114602.pdf |
| _version_ | 1824452434428166144 |
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| author | Kehinde, Samuel Abiodun Fatokun, Tolulope Peter Olajide, Abosede Temitope Praveena, Sarva Mangala Sokan-Adeaga, Adewale Allen Adekunle, Adegbola Philip Fouad, Dalia Papadakis, Marios |
| author_facet | Kehinde, Samuel Abiodun Fatokun, Tolulope Peter Olajide, Abosede Temitope Praveena, Sarva Mangala Sokan-Adeaga, Adewale Allen Adekunle, Adegbola Philip Fouad, Dalia Papadakis, Marios |
| author_sort | Kehinde, Samuel Abiodun |
| collection | UPM |
| description | The widespread presence of microplastics in the environment has raised significant concerns regarding their potential impact on human and animal health. Among various microplastic types, polyethylene microplastics (PE-MPs) are particularly prevalent due to the extensive use in packaging and consumer products. Exploring the uncharted therapeutic potentials of naringin, this study delves into its mitigating effects on disruptions in kallikrein-3 levels, steroidal-thyroidal hormone balance, and antioxidant defense triggered by PE-MPs exposure, paving the way for novel interventions in environmental toxin-induced endocrine and oxidative stress disorders. Male Wistar rats (n = 24) were randomly grouped into four: Control, PE-MPs (1.5 mg/kg), PE-MPs + NAR (1.5 mg/kg PE-MPs + 100 mg/kg NAR), and NAR (100 mg/kg). Hormonal and antioxidant parameters were assessed after 28 days of exposure. PE-MPs exposure caused a significant increase(p < 0.005) in the level of kallikrein-3 (KLK-3) while it significantly reduces the levels of testosterone (TST), luteinizing hormone, thyroid stimulating hormone (TSH) and Free-triiodothyronine (fT3) and Total cholesterol (TChol) concentration. PE-MPs exposure also disrupted significantly (p < 0.005) antioxidant profile by down-regulating the activities of glutathione-S-transferase, catalase (CAT), superoxide dismutase (SOD) and reducing levels of glutathione (GSH) and ascorbic acid (AA) while concentration of malondialdehyde (MDA) levels were increased relative to control. However, the mitigating potentials of naringin on disruptions in hormonal and antioxidant profiles caused by PE-MPs exposure were demonstrated, as NAR normalized KLK-3, steroid, and thyroid hormone levels, cholesterol concentration, and enhanced antioxidant defense. This suggests that NAR is a promising protective agent against endocrine and oxidative damage induced by environmental contaminants such as microplastics. |
| first_indexed | 2025-02-19T02:50:28Z |
| format | Article |
| id | upm.eprints-114602 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:50:28Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | upm.eprints-1146022025-01-23T07:55:52Z http://psasir.upm.edu.my/id/eprint/114602/ Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin Kehinde, Samuel Abiodun Fatokun, Tolulope Peter Olajide, Abosede Temitope Praveena, Sarva Mangala Sokan-Adeaga, Adewale Allen Adekunle, Adegbola Philip Fouad, Dalia Papadakis, Marios The widespread presence of microplastics in the environment has raised significant concerns regarding their potential impact on human and animal health. Among various microplastic types, polyethylene microplastics (PE-MPs) are particularly prevalent due to the extensive use in packaging and consumer products. Exploring the uncharted therapeutic potentials of naringin, this study delves into its mitigating effects on disruptions in kallikrein-3 levels, steroidal-thyroidal hormone balance, and antioxidant defense triggered by PE-MPs exposure, paving the way for novel interventions in environmental toxin-induced endocrine and oxidative stress disorders. Male Wistar rats (n = 24) were randomly grouped into four: Control, PE-MPs (1.5 mg/kg), PE-MPs + NAR (1.5 mg/kg PE-MPs + 100 mg/kg NAR), and NAR (100 mg/kg). Hormonal and antioxidant parameters were assessed after 28 days of exposure. PE-MPs exposure caused a significant increase(p < 0.005) in the level of kallikrein-3 (KLK-3) while it significantly reduces the levels of testosterone (TST), luteinizing hormone, thyroid stimulating hormone (TSH) and Free-triiodothyronine (fT3) and Total cholesterol (TChol) concentration. PE-MPs exposure also disrupted significantly (p < 0.005) antioxidant profile by down-regulating the activities of glutathione-S-transferase, catalase (CAT), superoxide dismutase (SOD) and reducing levels of glutathione (GSH) and ascorbic acid (AA) while concentration of malondialdehyde (MDA) levels were increased relative to control. However, the mitigating potentials of naringin on disruptions in hormonal and antioxidant profiles caused by PE-MPs exposure were demonstrated, as NAR normalized KLK-3, steroid, and thyroid hormone levels, cholesterol concentration, and enhanced antioxidant defense. This suggests that NAR is a promising protective agent against endocrine and oxidative damage induced by environmental contaminants such as microplastics. Nature Research 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114602/1/114602.pdf Kehinde, Samuel Abiodun and Fatokun, Tolulope Peter and Olajide, Abosede Temitope and Praveena, Sarva Mangala and Sokan-Adeaga, Adewale Allen and Adekunle, Adegbola Philip and Fouad, Dalia and Papadakis, Marios (2024) Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin. Scientific Reports, 14 (1). art. no. 23664. pp. 1-10. ISSN 2045-2322 https://www.nature.com/articles/s41598-024-74637-5?error=cookies_not_supported&code=161ee101-cd2c-48a7-980e-4a3c25fdcadc Pollution 10.1038/s41598-024-74637-5 |
| spellingShingle | Pollution Kehinde, Samuel Abiodun Fatokun, Tolulope Peter Olajide, Abosede Temitope Praveena, Sarva Mangala Sokan-Adeaga, Adewale Allen Adekunle, Adegbola Philip Fouad, Dalia Papadakis, Marios Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin |
| title | Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin |
| title_full | Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin |
| title_fullStr | Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin |
| title_full_unstemmed | Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin |
| title_short | Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin |
| title_sort | impact of polyethylene microplastics exposure on kallikrein 3 levels steroidal thyroidal hormones and antioxidant status in murine model protective potentials of naringin |
| topic | Pollution |
| url | http://psasir.upm.edu.my/id/eprint/114602/1/114602.pdf |
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