Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions
Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, withEscherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and wa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Veterinary World
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114877/1/114877.pdf |
| _version_ | 1824452484765057024 |
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| author | Fatokun, Omotayo Selvaraja, Malarvili Anuar, Haryati Tengku Jamaluddin, Tengku Zetty Maztura Syed Ismail, Sharifah Norkhadijah Mansor, Rozaihan Shah, Shamsul Azhar Oranye, Nelson |
| author_facet | Fatokun, Omotayo Selvaraja, Malarvili Anuar, Haryati Tengku Jamaluddin, Tengku Zetty Maztura Syed Ismail, Sharifah Norkhadijah Mansor, Rozaihan Shah, Shamsul Azhar Oranye, Nelson |
| author_sort | Fatokun, Omotayo |
| collection | UPM |
| description | Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, withEscherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and warm-blooded creatures, demonstrates wide ecological adaptability in both intestinal and extraintestinal habitats. This study explores the dynamics, implications, and future directions of antimicrobial-resistant E. coli (AREC) transmission and clinical significance. We investigated the spread of antibiotic-resistant strains among humans, animals, and the environment, illuminating the impact of healthcare and agriculture practices, as well as environmental contamination. The implications of AREC infections are addressed, emphasizing the challenges in treatment due to limited antibiotic options, increased morbidity and mortality rates, and economic burdens on healthcare systems and agriculture, as well as the urgent need for a One Health approach to combat AMR through collaborative efforts across disciplines. Proposed future directions encompass enhanced surveillance, innovative antimicrobial stewardship, and alternative treatment modalities. |
| first_indexed | 2025-02-19T02:51:16Z |
| format | Article |
| id | upm.eprints-114877 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:51:16Z |
| publishDate | 2024 |
| publisher | Veterinary World |
| record_format | dspace |
| spelling | upm.eprints-1148772025-02-06T04:10:42Z http://psasir.upm.edu.my/id/eprint/114877/ Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions Fatokun, Omotayo Selvaraja, Malarvili Anuar, Haryati Tengku Jamaluddin, Tengku Zetty Maztura Syed Ismail, Sharifah Norkhadijah Mansor, Rozaihan Shah, Shamsul Azhar Oranye, Nelson Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, withEscherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and warm-blooded creatures, demonstrates wide ecological adaptability in both intestinal and extraintestinal habitats. This study explores the dynamics, implications, and future directions of antimicrobial-resistant E. coli (AREC) transmission and clinical significance. We investigated the spread of antibiotic-resistant strains among humans, animals, and the environment, illuminating the impact of healthcare and agriculture practices, as well as environmental contamination. The implications of AREC infections are addressed, emphasizing the challenges in treatment due to limited antibiotic options, increased morbidity and mortality rates, and economic burdens on healthcare systems and agriculture, as well as the urgent need for a One Health approach to combat AMR through collaborative efforts across disciplines. Proposed future directions encompass enhanced surveillance, innovative antimicrobial stewardship, and alternative treatment modalities. Veterinary World 2024-07-25 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114877/1/114877.pdf Fatokun, Omotayo and Selvaraja, Malarvili and Anuar, Haryati and Tengku Jamaluddin, Tengku Zetty Maztura and Syed Ismail, Sharifah Norkhadijah and Mansor, Rozaihan and Shah, Shamsul Azhar and Oranye, Nelson (2024) Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions. International Journal of One Health, 10 (2). art. no. 1. pp. 161-171. ISSN 2455-5673; eISSN: 2455-8931 https://www.onehealthjournal.org/Vol.10/No.2/1.php 10.14202/IJOH.2024.161-171 |
| spellingShingle | Fatokun, Omotayo Selvaraja, Malarvili Anuar, Haryati Tengku Jamaluddin, Tengku Zetty Maztura Syed Ismail, Sharifah Norkhadijah Mansor, Rozaihan Shah, Shamsul Azhar Oranye, Nelson Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions |
| title | Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions |
| title_full | Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions |
| title_fullStr | Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions |
| title_full_unstemmed | Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions |
| title_short | Antimicrobial resistance at the human–animal–environment interface: a focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions |
| title_sort | antimicrobial resistance at the human animal environment interface a focus on antimicrobial resistant escherichia coli transmission dynamics clinical implications and future directions |
| url | http://psasir.upm.edu.my/id/eprint/114877/1/114877.pdf |
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