Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques
Introduction: The escalating global prevalence of complementary and alternative medicine is often linked to the financial challenges of conventional healthcare in developing nations. Trigonella foenum-graecum (TFG), commonly known as Fenugreek, it is rich in proteins, lipids, fatty acids, and minera...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Putra Malaysia Press
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114930/1/114930.pdf |
| _version_ | 1824452492907249664 |
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| author | Okorie, Nnaemeka Ibe, Onyekachi Ewa Okekpa, Simon Imakwu Nwakpa, Anthony Chukwudi Agom, Dansy Daniel Pauline, Iyke-Ogbo Adaeze, Obi Laura Mmesomachi, Uche Bethel Nyirahafashimana, Valentine Obi, Ihuoma A. |
| author_facet | Okorie, Nnaemeka Ibe, Onyekachi Ewa Okekpa, Simon Imakwu Nwakpa, Anthony Chukwudi Agom, Dansy Daniel Pauline, Iyke-Ogbo Adaeze, Obi Laura Mmesomachi, Uche Bethel Nyirahafashimana, Valentine Obi, Ihuoma A. |
| author_sort | Okorie, Nnaemeka |
| collection | UPM |
| description | Introduction: The escalating global prevalence of complementary and alternative medicine is often linked to the financial challenges of conventional healthcare in developing nations. Trigonella foenum-graecum (TFG), commonly known as Fenugreek, it is rich in proteins, lipids, fatty acids, and minerals, offering numerous health benefits. This study explores the hepatic impact of prolonged oral ingestion of an aqueous extract from Trigonella foenum-graecum seeds in Norvegicus rattus. Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. Liver tissues were harvested and processed, and blood samples collected through cardiac puncture for biochemical analysis, comparisons across all groups were performed for all tests using SPSS version 20, with statistical significance determined at p ≤ 0.05. Results: Trigonella foenum-graecum administration resulted in significant increases in serum ALT and AST levels, indicating potential hepatotoxicity. Lower doses exhibited reduced lipid peroxidation (MDA), while higher doses surpassed control group MDA levels, suggesting a dose-dependent response. Antioxidant enzymes (CAT, SOD, GSH, GPX) showed elevation at lower doses but declined at higher doses. Liver histological examinations revealed characteristics indicative of toxicity at higher doses. Conclusion: This study establishes the antioxidant and hepatoprotective properties of Trigonella foenum-graecum, highlighting a dose-dependent relationship. While lower doses show beneficial effects, higher doses may lead to adverse effects and liver damage. These findings contribute to understanding the dual nature of Trigonella foenum-graecum in therapeutic contexts. |
| first_indexed | 2025-02-19T02:51:23Z |
| format | Article |
| id | upm.eprints-114930 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:51:23Z |
| publishDate | 2024 |
| publisher | Universiti Putra Malaysia Press |
| record_format | dspace |
| spelling | upm.eprints-1149302025-02-12T03:04:00Z http://psasir.upm.edu.my/id/eprint/114930/ Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques Okorie, Nnaemeka Ibe, Onyekachi Ewa Okekpa, Simon Imakwu Nwakpa, Anthony Chukwudi Agom, Dansy Daniel Pauline, Iyke-Ogbo Adaeze, Obi Laura Mmesomachi, Uche Bethel Nyirahafashimana, Valentine Obi, Ihuoma A. Introduction: The escalating global prevalence of complementary and alternative medicine is often linked to the financial challenges of conventional healthcare in developing nations. Trigonella foenum-graecum (TFG), commonly known as Fenugreek, it is rich in proteins, lipids, fatty acids, and minerals, offering numerous health benefits. This study explores the hepatic impact of prolonged oral ingestion of an aqueous extract from Trigonella foenum-graecum seeds in Norvegicus rattus. Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. Liver tissues were harvested and processed, and blood samples collected through cardiac puncture for biochemical analysis, comparisons across all groups were performed for all tests using SPSS version 20, with statistical significance determined at p ≤ 0.05. Results: Trigonella foenum-graecum administration resulted in significant increases in serum ALT and AST levels, indicating potential hepatotoxicity. Lower doses exhibited reduced lipid peroxidation (MDA), while higher doses surpassed control group MDA levels, suggesting a dose-dependent response. Antioxidant enzymes (CAT, SOD, GSH, GPX) showed elevation at lower doses but declined at higher doses. Liver histological examinations revealed characteristics indicative of toxicity at higher doses. Conclusion: This study establishes the antioxidant and hepatoprotective properties of Trigonella foenum-graecum, highlighting a dose-dependent relationship. While lower doses show beneficial effects, higher doses may lead to adverse effects and liver damage. These findings contribute to understanding the dual nature of Trigonella foenum-graecum in therapeutic contexts. Universiti Putra Malaysia Press 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114930/1/114930.pdf Okorie, Nnaemeka and Ibe, Onyekachi Ewa and Okekpa, Simon Imakwu and Nwakpa, Anthony Chukwudi and Agom, Dansy Daniel and Pauline, Iyke-Ogbo and Adaeze, Obi Laura and Mmesomachi, Uche Bethel and Nyirahafashimana, Valentine and Obi, Ihuoma A. (2024) Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques. Malaysian Journal of Medicine and Health Sciences, 20 (6). pp. 208-218. ISSN 1675-8544; eISSN: 2636-9346 https://doi.org/10.47836%2Fmjmhs20.6.28 10.47836/mjmhs20.6.28 |
| spellingShingle | Okorie, Nnaemeka Ibe, Onyekachi Ewa Okekpa, Simon Imakwu Nwakpa, Anthony Chukwudi Agom, Dansy Daniel Pauline, Iyke-Ogbo Adaeze, Obi Laura Mmesomachi, Uche Bethel Nyirahafashimana, Valentine Obi, Ihuoma A. Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques |
| title | Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques |
| title_full | Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques |
| title_fullStr | Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques |
| title_full_unstemmed | Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques |
| title_short | Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques |
| title_sort | hepatic effects of prolonged oral administration of aqueous extracts from trigonella foenum graecum fenugreek seeds explored through pathology techniques |
| url | http://psasir.upm.edu.my/id/eprint/114930/1/114930.pdf |
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