Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling
The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. Th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
1998
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115037/1/115037.pdf |
| _version_ | 1824452514128330752 |
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| author | Noor, Hamdan Ashcroft, Stephen J. H. |
| author_facet | Noor, Hamdan Ashcroft, Stephen J. H. |
| author_sort | Noor, Hamdan |
| collection | UPM |
| description | The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. The increase in cytosolic Ca2+ concentration is due to stimulation of Ca2+ uptake from the extracellular medium and inhibition of Ca2+ efflux from the cytosol. That the mechanism of insulinotropic action of T. crispa is physiological suggests that the insulin secretagogue/s present in the extract could indeed be a potential source of a specific oral hypoglycaemic agent for the treatment of non-insulin-dependent diabetes mellitus. |
| first_indexed | 2025-02-19T02:51:44Z |
| format | Article |
| id | upm.eprints-115037 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:51:44Z |
| publishDate | 1998 |
| publisher | Wiley |
| record_format | dspace |
| spelling | upm.eprints-1150372025-02-18T03:00:48Z http://psasir.upm.edu.my/id/eprint/115037/ Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling Noor, Hamdan Ashcroft, Stephen J. H. The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. The increase in cytosolic Ca2+ concentration is due to stimulation of Ca2+ uptake from the extracellular medium and inhibition of Ca2+ efflux from the cytosol. That the mechanism of insulinotropic action of T. crispa is physiological suggests that the insulin secretagogue/s present in the extract could indeed be a potential source of a specific oral hypoglycaemic agent for the treatment of non-insulin-dependent diabetes mellitus. Wiley 1998 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115037/1/115037.pdf Noor, Hamdan and Ashcroft, Stephen J. H. (1998) Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling. Phytotherapy Research, 12 (2). pp. 98-102. ISSN 0951-418X; eISSN:1099-1573 https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1573(199803)12:2%3C98::AID-PTR195%3E3.0.CO;2-F 10.1002/(SICI)1099-1573(199803)12:2<98::AID-PTR195>3.0.CO;2-F |
| spellingShingle | Noor, Hamdan Ashcroft, Stephen J. H. Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling |
| title | Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling |
| title_full | Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling |
| title_fullStr | Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling |
| title_full_unstemmed | Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling |
| title_short | Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling |
| title_sort | insulinotropic activity of tinospora crispa extract effect on β cell ca2 handling |
| url | http://psasir.upm.edu.my/id/eprint/115037/1/115037.pdf |
| work_keys_str_mv | AT noorhamdan insulinotropicactivityoftinosporacrispaextracteffectonbcellca2handling AT ashcroftstephenjh insulinotropicactivityoftinosporacrispaextracteffectonbcellca2handling |