Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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Asia Pacific Association of Allergy, Asthma, and Clinical Immunology
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf |
| _version_ | 1825940651482546176 |
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| author | Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa |
| author_facet | Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa |
| author_sort | Ismail, Intan Hakimah |
| collection | UPM |
| description | Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement. |
| first_indexed | 2025-03-07T13:05:02Z |
| format | Conference or Workshop Item |
| id | upm.eprints-115329 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2025-03-07T13:05:02Z |
| publishDate | 2024 |
| publisher | Asia Pacific Association of Allergy, Asthma, and Clinical Immunology |
| record_format | dspace |
| spelling | upm.eprints-1153292025-03-03T05:11:03Z http://psasir.upm.edu.my/id/eprint/115329/ Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement. Asia Pacific Association of Allergy, Asthma, and Clinical Immunology 2024 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf Ismail, Intan Hakimah and Zainal Abidin, Mohd Azri and Mohamed Nashrudin, Khairoon Nisa (2024) Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome. In: Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) Congress 2024, 13-15 Dec. 2024, Kuala Lumpur, Malaysia. . |
| spellingShingle | Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
| title | Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
| title_full | Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
| title_fullStr | Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
| title_full_unstemmed | Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
| title_short | Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
| title_sort | aspergilloma in a young patient with autosomal dominant hyper ige syndrome |
| url | http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf |
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