Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils
Virgin coconut oil (VCO), or in Malays known as ‘minyak kelapa dara’, has gain a lot of attention recently due to various medicinal values. The aim of the present study was to evaluate the effect of feeding two types of VCOs, VCOA (produced via a standard drying method) or VCOB (prepared via ferment...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academic Journals
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13144/1/Antihypercholesterolemia%20property%20and%20fatty%20acid%20composition%20of%20MARDI.pdf |
| _version_ | 1796968371945734144 |
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| author | Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul Abd. Kadir, Arifah Hussain, Mohd Khairi Sulaiman, Mohd Roslan Teh, Lay Kek Salleh, Mohd. Zaki Long, Kamariah |
| author_facet | Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul Abd. Kadir, Arifah Hussain, Mohd Khairi Sulaiman, Mohd Roslan Teh, Lay Kek Salleh, Mohd. Zaki Long, Kamariah |
| author_sort | Zakaria, Zainul Amiruddin |
| collection | UPM |
| description | Virgin coconut oil (VCO), or in Malays known as ‘minyak kelapa dara’, has gain a lot of attention recently due to various medicinal values. The aim of the present study was to evaluate the effect of feeding two types of VCOs, VCOA (produced via a standard drying method) or VCOB (prepared via fermentation process), that were produced by Malaysia Agriculture Research and Development Institute (MARDI) in lowering the plasma lipid parameter in rabbits. Nine groups of New Zealand White male rabbits (n = 6/group) were used in this study. Group 1 and 2 animals were treated with 0.9% normal saline, but fed either with a normal or cholesterol-added diet (negative control), respectively. Group 3 - 5 and 6 - 8 were given orally with the different volume (0.5, 1.0 and 2.5 ml/kg/day) of VCOA or VCOB followed by the cholesterol-added diet. Group 9 were treated with 5 mg/kg Atorvastatin and fed a cholesterol-added diet. All groups were treated for 8 weeks and blood samples were taken from the marginal ear vein prior to treatment (day 0), weeks 4 and 8 for the analysis of plasma. The rabbits fed with different volume of VCOs showed significant (P < 0.05) reduction in plasma cholesterol and LDL cholesterol levels compared to the control group in weeks 4 and 8. The triglycerides level increased significantly (P < 0.05) on week 4 before reduced on week 8, to a level that is still significant when compared to week 0. The HDL level also increased significantly (P < 0.05) on weeks 4 and 8 after treatment. Fatty acid analysis revealed the presence of all important fatty acids. Both VCOs showed insignificant effect on all parameters measured when compared together. In conclusion, the MARDI-produced VCOs appeared to possess great potentials as antihypercholesterolemic agent that required further in-depth study. |
| first_indexed | 2024-03-06T07:27:29Z |
| format | Article |
| id | upm.eprints-13144 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:27:29Z |
| publishDate | 2010 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | upm.eprints-131442015-11-24T03:42:48Z http://psasir.upm.edu.my/id/eprint/13144/ Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul Abd. Kadir, Arifah Hussain, Mohd Khairi Sulaiman, Mohd Roslan Teh, Lay Kek Salleh, Mohd. Zaki Long, Kamariah Virgin coconut oil (VCO), or in Malays known as ‘minyak kelapa dara’, has gain a lot of attention recently due to various medicinal values. The aim of the present study was to evaluate the effect of feeding two types of VCOs, VCOA (produced via a standard drying method) or VCOB (prepared via fermentation process), that were produced by Malaysia Agriculture Research and Development Institute (MARDI) in lowering the plasma lipid parameter in rabbits. Nine groups of New Zealand White male rabbits (n = 6/group) were used in this study. Group 1 and 2 animals were treated with 0.9% normal saline, but fed either with a normal or cholesterol-added diet (negative control), respectively. Group 3 - 5 and 6 - 8 were given orally with the different volume (0.5, 1.0 and 2.5 ml/kg/day) of VCOA or VCOB followed by the cholesterol-added diet. Group 9 were treated with 5 mg/kg Atorvastatin and fed a cholesterol-added diet. All groups were treated for 8 weeks and blood samples were taken from the marginal ear vein prior to treatment (day 0), weeks 4 and 8 for the analysis of plasma. The rabbits fed with different volume of VCOs showed significant (P < 0.05) reduction in plasma cholesterol and LDL cholesterol levels compared to the control group in weeks 4 and 8. The triglycerides level increased significantly (P < 0.05) on week 4 before reduced on week 8, to a level that is still significant when compared to week 0. The HDL level also increased significantly (P < 0.05) on weeks 4 and 8 after treatment. Fatty acid analysis revealed the presence of all important fatty acids. Both VCOs showed insignificant effect on all parameters measured when compared together. In conclusion, the MARDI-produced VCOs appeared to possess great potentials as antihypercholesterolemic agent that required further in-depth study. Academic Journals 2010-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13144/1/Antihypercholesterolemia%20property%20and%20fatty%20acid%20composition%20of%20MARDI.pdf Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Somchit, Muhammad Nazrul and Abd. Kadir, Arifah and Hussain, Mohd Khairi and Sulaiman, Mohd Roslan and Teh, Lay Kek and Salleh, Mohd. Zaki and Long, Kamariah (2010) Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils. African Journal of Pharmacy and Pharmacology, 4 (9). pp. 636-644. ISSN 1996-0816 http://www.academicjournals.org/journal/AJPP/article-abstract/46CFFE127094 |
| spellingShingle | Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul Abd. Kadir, Arifah Hussain, Mohd Khairi Sulaiman, Mohd Roslan Teh, Lay Kek Salleh, Mohd. Zaki Long, Kamariah Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils |
| title | Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils |
| title_full | Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils |
| title_fullStr | Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils |
| title_full_unstemmed | Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils |
| title_short | Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils |
| title_sort | antihypercholesterolemia property and fatty acid composition of mardi produced virgin coconut oils |
| url | http://psasir.upm.edu.my/id/eprint/13144/1/Antihypercholesterolemia%20property%20and%20fatty%20acid%20composition%20of%20MARDI.pdf |
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