Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice
The present study examined the potential antinociceptive activity of flavokawin B (6'-hydroxy-2',4'-dimethoxychalcone), a synthetic chalcone using chemical- and thermal-induced nociception models in mice. It was demonstrated that flavokawin B (FKB; 0.3, 1, 3 and 10 mg/kg) administered...
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| Format: | Article |
| Language: | English |
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Elsevier
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13161/1/Antinociceptive%20activity%20of%20a%20synthetic%20chalcone.pdf |
| _version_ | 1825945183275974656 |
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| author | Tengku Mohamad, Tengku Azam Shah Akhtar, Mohamad Nadeem Zakaria, Zainul Amiruddin Perimal, Enoch Kumar Khalid, Syamimi P. A. Mohd, Khalid, Mohamed Hanief Israf Ali, Daud Ahmad Lajis, Md. Nordin Sulaiman, Mohd Roslan |
| author_facet | Tengku Mohamad, Tengku Azam Shah Akhtar, Mohamad Nadeem Zakaria, Zainul Amiruddin Perimal, Enoch Kumar Khalid, Syamimi P. A. Mohd, Khalid, Mohamed Hanief Israf Ali, Daud Ahmad Lajis, Md. Nordin Sulaiman, Mohd Roslan |
| author_sort | Tengku Mohamad, Tengku Azam Shah |
| collection | UPM |
| description | The present study examined the potential antinociceptive activity of flavokawin B (6'-hydroxy-2',4'-dimethoxychalcone), a synthetic chalcone using chemical- and thermal-induced nociception models in mice. It was demonstrated that flavokawin B (FKB; 0.3, 1, 3 and 10 mg/kg) administered via both oral (p.o.) and intraperitoneal (i.p.) routes produced significant and dose-dependent inhibition in the abdominal constrictions induced by acetic acid, with the i.p. route producing antinociception of approximately 7-fold more potent than the p.o. route. It was also demonstrated that FKB produced significant inhibition in the two phases of the formalin-induced paw licking test. In addition, the same treatment of flavokawin B (FKB) exhibited significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin. Likewise, this compound also induced a significant increase in the response latency period to thermal stimuli in the hot plate test and its antinociceptive effect was not related to muscle relaxant or sedative action. Moreover, the antinociception effect of the FKB in the formalin-induced paw licking test and the hot plate test was not affected by pretreatment of non-selective opioid receptor antagonist, naloxone. The present results indicate that FKB produced pronounced antinociception effect against both chemical and thermal models of pain in mice that exhibited both peripheral and central analgesic activity. |
| first_indexed | 2024-03-06T07:27:32Z |
| format | Article |
| id | upm.eprints-13161 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:27:32Z |
| publishDate | 2010 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-131612016-04-22T01:20:20Z http://psasir.upm.edu.my/id/eprint/13161/ Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice Tengku Mohamad, Tengku Azam Shah Akhtar, Mohamad Nadeem Zakaria, Zainul Amiruddin Perimal, Enoch Kumar Khalid, Syamimi P. A. Mohd, Khalid, Mohamed Hanief Israf Ali, Daud Ahmad Lajis, Md. Nordin Sulaiman, Mohd Roslan The present study examined the potential antinociceptive activity of flavokawin B (6'-hydroxy-2',4'-dimethoxychalcone), a synthetic chalcone using chemical- and thermal-induced nociception models in mice. It was demonstrated that flavokawin B (FKB; 0.3, 1, 3 and 10 mg/kg) administered via both oral (p.o.) and intraperitoneal (i.p.) routes produced significant and dose-dependent inhibition in the abdominal constrictions induced by acetic acid, with the i.p. route producing antinociception of approximately 7-fold more potent than the p.o. route. It was also demonstrated that FKB produced significant inhibition in the two phases of the formalin-induced paw licking test. In addition, the same treatment of flavokawin B (FKB) exhibited significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin. Likewise, this compound also induced a significant increase in the response latency period to thermal stimuli in the hot plate test and its antinociceptive effect was not related to muscle relaxant or sedative action. Moreover, the antinociception effect of the FKB in the formalin-induced paw licking test and the hot plate test was not affected by pretreatment of non-selective opioid receptor antagonist, naloxone. The present results indicate that FKB produced pronounced antinociception effect against both chemical and thermal models of pain in mice that exhibited both peripheral and central analgesic activity. Elsevier 2010-11-25 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13161/1/Antinociceptive%20activity%20of%20a%20synthetic%20chalcone.pdf Tengku Mohamad, Tengku Azam Shah and Akhtar, Mohamad Nadeem and Zakaria, Zainul Amiruddin and Perimal, Enoch Kumar and Khalid, Syamimi and P. A. Mohd, and Khalid, Mohamed Hanief and Israf Ali, Daud Ahmad and Lajis, Md. Nordin and Sulaiman, Mohd Roslan (2010) Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice. European Journal of Pharmacology, 647 (1-3). pp. 103-109. ISSN 0014-2999; ESSN: 1879-0712 10.1016/j.ejphar.2010.08.030 |
| spellingShingle | Tengku Mohamad, Tengku Azam Shah Akhtar, Mohamad Nadeem Zakaria, Zainul Amiruddin Perimal, Enoch Kumar Khalid, Syamimi P. A. Mohd, Khalid, Mohamed Hanief Israf Ali, Daud Ahmad Lajis, Md. Nordin Sulaiman, Mohd Roslan Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice |
| title | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice |
| title_full | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice |
| title_fullStr | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice |
| title_full_unstemmed | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice |
| title_short | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice |
| title_sort | antinociceptive activity of a synthetic chalcone flavokawin b on chemical and thermal models of nociception in mice |
| url | http://psasir.upm.edu.my/id/eprint/13161/1/Antinociceptive%20activity%20of%20a%20synthetic%20chalcone.pdf |
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