Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models.
The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, whil...
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| Format: | Article |
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SAGE Publications
2010
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| author | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Rahman, Ab Abdul Tengku Mohamad, Tengku Azam Shah Mohd Desa, Mohd Nasir Stanslas, Johnson Moin, Saidi Israf Ali, Daud Ahmad |
| author_facet | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Rahman, Ab Abdul Tengku Mohamad, Tengku Azam Shah Mohd Desa, Mohd Nasir Stanslas, Johnson Moin, Saidi Israf Ali, Daud Ahmad |
| author_sort | Sulaiman, Mohd Roslan |
| collection | UPM |
| description | The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic activity was measured using the carrageenan-induced paw edema test. Subcutaneous (s.c.) administration of andrographolide (10, 25, and 50 mg/kg) did not affect the motor coordination of the experimental animals but produced significant (p <.05) antinociceptive activity when assessed using both tests. However, 2 mg/kg naloxone failed to affect the 25 mg/kg andrographolide activity in both tests, indicating that the activity was modulated via nonopioid mechanisms. Furthermore, andrographolide showed significant (p <.05) antiedematogenic activity. In conclusion, the results obtained suggest that andrographolide has antinociceptive and antiedematogenic activities; it may be useful for treating pain and inflammation once human studies are conducted. |
| first_indexed | 2024-03-06T07:27:32Z |
| format | Article |
| id | upm.eprints-13164 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T07:27:32Z |
| publishDate | 2010 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | upm.eprints-131642014-12-06T02:34:54Z http://psasir.upm.edu.my/id/eprint/13164/ Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Rahman, Ab Abdul Tengku Mohamad, Tengku Azam Shah Mohd Desa, Mohd Nasir Stanslas, Johnson Moin, Saidi Israf Ali, Daud Ahmad The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic activity was measured using the carrageenan-induced paw edema test. Subcutaneous (s.c.) administration of andrographolide (10, 25, and 50 mg/kg) did not affect the motor coordination of the experimental animals but produced significant (p <.05) antinociceptive activity when assessed using both tests. However, 2 mg/kg naloxone failed to affect the 25 mg/kg andrographolide activity in both tests, indicating that the activity was modulated via nonopioid mechanisms. Furthermore, andrographolide showed significant (p <.05) antiedematogenic activity. In conclusion, the results obtained suggest that andrographolide has antinociceptive and antiedematogenic activities; it may be useful for treating pain and inflammation once human studies are conducted. SAGE Publications 2010-01 Article PeerReviewed Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Rahman, Ab Abdul and Tengku Mohamad, Tengku Azam Shah and Mohd Desa, Mohd Nasir and Stanslas, Johnson and Moin, Saidi and Israf Ali, Daud Ahmad (2010) Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. Biological Research For Nursing, 11 (3). pp. 293-301. ISSN 1099-8004; ESSN: 1552-4175 10.1177/1099800409343311 |
| spellingShingle | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Rahman, Ab Abdul Tengku Mohamad, Tengku Azam Shah Mohd Desa, Mohd Nasir Stanslas, Johnson Moin, Saidi Israf Ali, Daud Ahmad Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. |
| title | Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. |
| title_full | Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. |
| title_fullStr | Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. |
| title_full_unstemmed | Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. |
| title_short | Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. |
| title_sort | antinociceptive and antiedematogenic activities of andrographolide isolated from andrographis paniculata in animal models |
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