Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models.
This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in dis...
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| Format: | Article |
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Springer Verlag
2008
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| author | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Israf Ali, Daud Ahmad Ng, F. N. Ng, Y. C. Baharuldin, Mohamad Taufik Hidayat |
| author_facet | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Israf Ali, Daud Ahmad Ng, F. N. Ng, Y. C. Baharuldin, Mohamad Taufik Hidayat |
| author_sort | Sulaiman, Mohd Roslan |
| collection | UPM |
| description | This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH2O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc. |
| first_indexed | 2024-03-06T07:27:32Z |
| format | Article |
| id | upm.eprints-13165 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T07:27:32Z |
| publishDate | 2008 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | upm.eprints-131652014-12-06T03:27:39Z http://psasir.upm.edu.my/id/eprint/13165/ Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Israf Ali, Daud Ahmad Ng, F. N. Ng, Y. C. Baharuldin, Mohamad Taufik Hidayat This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH2O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc. Springer Verlag 2008-04 Article PeerReviewed Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Israf Ali, Daud Ahmad and Ng, F. N. and Ng, Y. C. and Baharuldin, Mohamad Taufik Hidayat (2008) Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. Journal of Natural Medicines, 62 (2). pp. 221-227. ISSN 1340-3443; ESSN: 1861-0293 10.1007/s11418-007-0210-3 |
| spellingShingle | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Israf Ali, Daud Ahmad Ng, F. N. Ng, Y. C. Baharuldin, Mohamad Taufik Hidayat Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. |
| title | Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. |
| title_full | Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. |
| title_fullStr | Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. |
| title_full_unstemmed | Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. |
| title_short | Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. |
| title_sort | antinociceptive and anti inflammatory activities of the aqueous extract of kaempferia galanga leaves in animal models |
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