Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus

Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric meth...

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Bibliographic Details
Main Authors: Ee, Gwendoline Cheng Lian, Siow, Hwa Teo, Rahmani, Mawardi, Lim, Chan Kiang, Lim, Yang Mooi, Bong, Joseph Choon Fah
Format: Article
Language:English
Published: Bentham Science Publishers Ltd. 2010
Online Access:http://psasir.upm.edu.my/id/eprint/13279/1/Artosimmin.pdf
Description
Summary:Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).