Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus
Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric meth...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bentham Science Publishers Ltd.
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13279/1/Artosimmin.pdf |
| _version_ | 1796968399753969664 |
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| author | Ee, Gwendoline Cheng Lian Siow, Hwa Teo Rahmani, Mawardi Lim, Chan Kiang Lim, Yang Mooi Bong, Joseph Choon Fah |
| author_facet | Ee, Gwendoline Cheng Lian Siow, Hwa Teo Rahmani, Mawardi Lim, Chan Kiang Lim, Yang Mooi Bong, Joseph Choon Fah |
| author_sort | Ee, Gwendoline Cheng Lian |
| collection | UPM |
| description | Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). |
| first_indexed | 2024-03-06T07:27:53Z |
| format | Article |
| id | upm.eprints-13279 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:27:53Z |
| publishDate | 2010 |
| publisher | Bentham Science Publishers Ltd. |
| record_format | dspace |
| spelling | upm.eprints-132792015-09-10T04:05:54Z http://psasir.upm.edu.my/id/eprint/13279/ Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus Ee, Gwendoline Cheng Lian Siow, Hwa Teo Rahmani, Mawardi Lim, Chan Kiang Lim, Yang Mooi Bong, Joseph Choon Fah Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). Bentham Science Publishers Ltd. 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13279/1/Artosimmin.pdf Ee, Gwendoline Cheng Lian and Siow, Hwa Teo and Rahmani, Mawardi and Lim, Chan Kiang and Lim, Yang Mooi and Bong, Joseph Choon Fah (2010) Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus. Letters in Organic Chemistry, 7 (3). pp. 240-244. ISSN 1570-1786; ESSN: 1875-6255 10.2174/157017810791112379 |
| spellingShingle | Ee, Gwendoline Cheng Lian Siow, Hwa Teo Rahmani, Mawardi Lim, Chan Kiang Lim, Yang Mooi Bong, Joseph Choon Fah Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus |
| title | Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus |
| title_full | Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus |
| title_fullStr | Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus |
| title_full_unstemmed | Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus |
| title_short | Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus |
| title_sort | artosimmin potential anti cancer lead compound from artocarpus odoratissimus |
| url | http://psasir.upm.edu.my/id/eprint/13279/1/Artosimmin.pdf |
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