Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes.
African trypanosomes go through at least five developmental stages during their life cycle. The different cellular forms are classified using morphology, including the order of the nucleus, flagellum and kinetoplast along the anterior–posterior axis of the cell, the predominant cell surface molecule...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Urban und Fischer Verlag Jena
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13319/1/Asymmetric%20cell%20division%20as%20a%20route%20to%20reduction%20in%20cell%20length%20and%20change%20in%20cell%20morphology%20in%20trypanosomes.pdf |
| _version_ | 1825945213825187840 |
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| author | Kumar Sharma, Reuben Sunil Peacock, Lori Gluenz, Eva Gull , Keith Gibson, Wendy Carrington, Mark |
| author_facet | Kumar Sharma, Reuben Sunil Peacock, Lori Gluenz, Eva Gull , Keith Gibson, Wendy Carrington, Mark |
| author_sort | Kumar Sharma, Reuben Sunil |
| collection | UPM |
| description | African trypanosomes go through at least five developmental stages during their life cycle. The different cellular forms are classified using morphology, including the order of the nucleus, flagellum and kinetoplast along the anterior–posterior axis of the cell, the predominant cell surface molecules and the location within the host. Here, an asymmetrical cell division cycle that is an integral part of the Trypanosoma brucei life cycle has been characterised in further detail through the use of cell cycle stage specific markers. The cell cycle leading to the asymmetric division includes an exquisitely synchronised mitosis and exchange in relative location of organelles along the anterior–posterior axis of the cell. These events are coupled to a change in cell surface architecture. During the asymmetric division, the behaviour of the new flagellum is consistent with a role in determining the location of the plane of cell division, a function previously characterised in procyclic cells. Thus, the asymmetric cell division cycle provides a mechanism for a change in cell morphology and also an explanation for how a reduction in cell length can occur in a cell shaped by a stable microtubule array. |
| first_indexed | 2024-03-06T07:28:00Z |
| format | Article |
| id | upm.eprints-13319 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:28:00Z |
| publishDate | 2008 |
| publisher | Urban und Fischer Verlag Jena |
| record_format | dspace |
| spelling | upm.eprints-133192015-09-28T04:03:15Z http://psasir.upm.edu.my/id/eprint/13319/ Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Kumar Sharma, Reuben Sunil Peacock, Lori Gluenz, Eva Gull , Keith Gibson, Wendy Carrington, Mark African trypanosomes go through at least five developmental stages during their life cycle. The different cellular forms are classified using morphology, including the order of the nucleus, flagellum and kinetoplast along the anterior–posterior axis of the cell, the predominant cell surface molecules and the location within the host. Here, an asymmetrical cell division cycle that is an integral part of the Trypanosoma brucei life cycle has been characterised in further detail through the use of cell cycle stage specific markers. The cell cycle leading to the asymmetric division includes an exquisitely synchronised mitosis and exchange in relative location of organelles along the anterior–posterior axis of the cell. These events are coupled to a change in cell surface architecture. During the asymmetric division, the behaviour of the new flagellum is consistent with a role in determining the location of the plane of cell division, a function previously characterised in procyclic cells. Thus, the asymmetric cell division cycle provides a mechanism for a change in cell morphology and also an explanation for how a reduction in cell length can occur in a cell shaped by a stable microtubule array. Urban und Fischer Verlag Jena 2008-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13319/1/Asymmetric%20cell%20division%20as%20a%20route%20to%20reduction%20in%20cell%20length%20and%20change%20in%20cell%20morphology%20in%20trypanosomes.pdf Kumar Sharma, Reuben Sunil and Peacock, Lori and Gluenz, Eva and Gull , Keith and Gibson, Wendy and Carrington, Mark (2008) Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Protist, 159 (1). pp. 137-151. ISSN 1434-4610 10.1016/j.protis.2007.07.004 English |
| spellingShingle | Kumar Sharma, Reuben Sunil Peacock, Lori Gluenz, Eva Gull , Keith Gibson, Wendy Carrington, Mark Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. |
| title | Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. |
| title_full | Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. |
| title_fullStr | Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. |
| title_full_unstemmed | Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. |
| title_short | Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. |
| title_sort | asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes |
| url | http://psasir.upm.edu.my/id/eprint/13319/1/Asymmetric%20cell%20division%20as%20a%20route%20to%20reduction%20in%20cell%20length%20and%20change%20in%20cell%20morphology%20in%20trypanosomes.pdf |
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