Cis-clerodane-type furanoditerpenoids from Tinospora crispa
Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, b...
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| Format: | Article |
| Language: | English |
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American Chemical Society
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13597/1/Cis-clerodane-type%20furanoditerpenoids%20from%20Tinospora%20crispa.pdf |
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| author | Choudhary, Muhammad Iqbal Muhammad Ismail, Shaari, Khozirah Ahmed Abbaskhan, A. Sattar, Samina Lajis, Md. Nordin Atta-ur-Rahman, |
| author_facet | Choudhary, Muhammad Iqbal Muhammad Ismail, Shaari, Khozirah Ahmed Abbaskhan, A. Sattar, Samina Lajis, Md. Nordin Atta-ur-Rahman, |
| author_sort | Choudhary, Muhammad Iqbal |
| collection | UPM |
| description | Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, borapetoside A (13), were revised on the basis of HMQC and HMBC correlations. No discernible activity was observed when compounds 10-13 were subjected to evaluation in cytotoxicity assays against human prostate cancer (PC-3) and the normal mouse fibroblast (3T3) cell lines. |
| first_indexed | 2024-03-06T07:28:49Z |
| format | Article |
| id | upm.eprints-13597 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:28:49Z |
| publishDate | 2010 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | upm.eprints-135972015-11-02T03:54:40Z http://psasir.upm.edu.my/id/eprint/13597/ Cis-clerodane-type furanoditerpenoids from Tinospora crispa Choudhary, Muhammad Iqbal Muhammad Ismail, Shaari, Khozirah Ahmed Abbaskhan, A. Sattar, Samina Lajis, Md. Nordin Atta-ur-Rahman, Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, borapetoside A (13), were revised on the basis of HMQC and HMBC correlations. No discernible activity was observed when compounds 10-13 were subjected to evaluation in cytotoxicity assays against human prostate cancer (PC-3) and the normal mouse fibroblast (3T3) cell lines. American Chemical Society 2010-04-23 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13597/1/Cis-clerodane-type%20furanoditerpenoids%20from%20Tinospora%20crispa.pdf Choudhary, Muhammad Iqbal and Muhammad Ismail, and Shaari, Khozirah and Ahmed Abbaskhan, and A. Sattar, Samina and Lajis, Md. Nordin and Atta-ur-Rahman, (2010) Cis-clerodane-type furanoditerpenoids from Tinospora crispa. Journal of Natural Products, 73 (4). pp. 541-547. ISSN 0163-3864; ISSN: 1520-6025 http://pubs.acs.org/doi/abs/10.1021/np900551u 10.1021/np900551u. |
| spellingShingle | Choudhary, Muhammad Iqbal Muhammad Ismail, Shaari, Khozirah Ahmed Abbaskhan, A. Sattar, Samina Lajis, Md. Nordin Atta-ur-Rahman, Cis-clerodane-type furanoditerpenoids from Tinospora crispa |
| title | Cis-clerodane-type furanoditerpenoids from Tinospora crispa |
| title_full | Cis-clerodane-type furanoditerpenoids from Tinospora crispa |
| title_fullStr | Cis-clerodane-type furanoditerpenoids from Tinospora crispa |
| title_full_unstemmed | Cis-clerodane-type furanoditerpenoids from Tinospora crispa |
| title_short | Cis-clerodane-type furanoditerpenoids from Tinospora crispa |
| title_sort | cis clerodane type furanoditerpenoids from tinospora crispa |
| url | http://psasir.upm.edu.my/id/eprint/13597/1/Cis-clerodane-type%20furanoditerpenoids%20from%20Tinospora%20crispa.pdf |
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