Clinical features and risk factors for HIV encephalopathy in children
A prospective cohort study was conducted to determine the incidence of progressive encephalopathy (PE) and its associated clinical manifestations amongst a cohort of HIV infected children attending the HIV/AIDS clinic of the Pediatric Institute, Kuala Lumpur Hospital, Malaysia. Neurological and neu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Regional Tropical Medicine & Public Health Project
2008
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/13607/1/Clinical%20features%20and%20risk%20factors%20for%20HIV%20encephalopathy%20in%20children.pdf |
| _version_ | 1796968471101177856 |
|---|---|
| author | Abd Hamid, Mohd Zaini Aziz, Noor Azah Syed Zakaria, Syed Zulkifli Othman, Norlijah Mohd Razali, Kamarul Azhar |
| author_facet | Abd Hamid, Mohd Zaini Aziz, Noor Azah Syed Zakaria, Syed Zulkifli Othman, Norlijah Mohd Razali, Kamarul Azhar |
| author_sort | Abd Hamid, Mohd Zaini |
| collection | UPM |
| description | A prospective cohort study was conducted to determine the incidence of progressive encephalopathy (PE) and its associated clinical manifestations amongst a cohort of HIV
infected children attending the HIV/AIDS clinic of the Pediatric Institute, Kuala Lumpur Hospital, Malaysia. Neurological and neurobehavioral assessments were performed in 55 children with HIV over a 24-month study period. Parameters assessed were physical and neurological
assessments, CD4 counts, CD4 percentages, RNA viral loads and an IQ assessment at four monthly intervals. PE was diagnosed when patient developed at least one of the definitive criteria for PE based on the Consensus of Pediatric Neurology / Psychology Working Group, AIDS Clinical Trial 1996. The incidence of encephalopathy was 18.2% (n=10) in 2002. All the patients had hepatosplenomegaly, lymphadenopathy, abnormal deep tendon reflexes and five had impairment in brain growth. The CD4 counts and CD4 percentages were more likely to be associated with PE compared to the non-PE group. |
| first_indexed | 2024-03-06T07:28:51Z |
| format | Article |
| id | upm.eprints-13607 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:28:51Z |
| publishDate | 2008 |
| publisher | Regional Tropical Medicine & Public Health Project |
| record_format | dspace |
| spelling | upm.eprints-136072015-12-02T03:08:01Z http://psasir.upm.edu.my/id/eprint/13607/ Clinical features and risk factors for HIV encephalopathy in children Abd Hamid, Mohd Zaini Aziz, Noor Azah Syed Zakaria, Syed Zulkifli Othman, Norlijah Mohd Razali, Kamarul Azhar A prospective cohort study was conducted to determine the incidence of progressive encephalopathy (PE) and its associated clinical manifestations amongst a cohort of HIV infected children attending the HIV/AIDS clinic of the Pediatric Institute, Kuala Lumpur Hospital, Malaysia. Neurological and neurobehavioral assessments were performed in 55 children with HIV over a 24-month study period. Parameters assessed were physical and neurological assessments, CD4 counts, CD4 percentages, RNA viral loads and an IQ assessment at four monthly intervals. PE was diagnosed when patient developed at least one of the definitive criteria for PE based on the Consensus of Pediatric Neurology / Psychology Working Group, AIDS Clinical Trial 1996. The incidence of encephalopathy was 18.2% (n=10) in 2002. All the patients had hepatosplenomegaly, lymphadenopathy, abnormal deep tendon reflexes and five had impairment in brain growth. The CD4 counts and CD4 percentages were more likely to be associated with PE compared to the non-PE group. Regional Tropical Medicine & Public Health Project 2008-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13607/1/Clinical%20features%20and%20risk%20factors%20for%20HIV%20encephalopathy%20in%20children.pdf Abd Hamid, Mohd Zaini and Aziz, Noor Azah and Syed Zakaria, Syed Zulkifli and Othman, Norlijah and Mohd Razali, Kamarul Azhar (2008) Clinical features and risk factors for HIV encephalopathy in children. The Southeast Asian Journal of Tropical Medicine and Public Health, 39 (2). pp. 266-272. ISSN 0125-1562 http://www.tm.mahidol.ac.th/seameo/journal_39_2_2008.html |
| spellingShingle | Abd Hamid, Mohd Zaini Aziz, Noor Azah Syed Zakaria, Syed Zulkifli Othman, Norlijah Mohd Razali, Kamarul Azhar Clinical features and risk factors for HIV encephalopathy in children |
| title | Clinical features and risk factors for HIV encephalopathy in children |
| title_full | Clinical features and risk factors for HIV encephalopathy in children |
| title_fullStr | Clinical features and risk factors for HIV encephalopathy in children |
| title_full_unstemmed | Clinical features and risk factors for HIV encephalopathy in children |
| title_short | Clinical features and risk factors for HIV encephalopathy in children |
| title_sort | clinical features and risk factors for hiv encephalopathy in children |
| url | http://psasir.upm.edu.my/id/eprint/13607/1/Clinical%20features%20and%20risk%20factors%20for%20HIV%20encephalopathy%20in%20children.pdf |
| work_keys_str_mv | AT abdhamidmohdzaini clinicalfeaturesandriskfactorsforhivencephalopathyinchildren AT aziznoorazah clinicalfeaturesandriskfactorsforhivencephalopathyinchildren AT syedzakariasyedzulkifli clinicalfeaturesandriskfactorsforhivencephalopathyinchildren AT othmannorlijah clinicalfeaturesandriskfactorsforhivencephalopathyinchildren AT mohdrazalikamarulazhar clinicalfeaturesandriskfactorsforhivencephalopathyinchildren |