Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
A set of copper(II) complexes of glycine and methylated glycine derivatives, Cu(aa)2, consisting of C-dimethylglycine, l-alanine, N-dimethylglycine and sarcosine, was investigated for their DNA binding and nucleolytic properties by means of EPR and visible spectroscopy, and electrophoresis. They bin...
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| Format: | Article |
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Pergamon Press
2009
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| _version_ | 1796968513128103936 |
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| author | Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee |
| author_facet | Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee |
| author_sort | Seng, Hoi Ling |
| collection | UPM |
| description | A set of copper(II) complexes of glycine and methylated glycine derivatives, Cu(aa)2, consisting of C-dimethylglycine, l-alanine, N-dimethylglycine and sarcosine, was investigated for their DNA binding and nucleolytic properties by means of EPR and visible spectroscopy, and electrophoresis. They bind weakly to DNA with apparent binding constants in the range 1.8–2.9 × 103 M−1 with very similar orientation. No DNA cleavage is observed in the absence of exogenous agents. Copper(II) complexes of N-methylated derivatives bind to DNA more stereo-specifically and less strongly, and their oxidative DNA cleavage is less efficient than those of the corresponding C-methylated derivatives in the presence of hydrogen peroxide (H2O2) alone, or sodium ascorbate (NaHA) alone or tandem H2O2–NaHA. The oxidative DNA cleavage mechanism in the three systems involves a common copper(I) species. Neocuproine can inhibit DNA cleavage by these complexes.
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| first_indexed | 2024-03-06T07:29:25Z |
| format | Article |
| id | upm.eprints-13796 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T07:29:25Z |
| publishDate | 2009 |
| publisher | Pergamon Press |
| record_format | dspace |
| spelling | upm.eprints-137962015-06-17T08:12:21Z http://psasir.upm.edu.my/id/eprint/13796/ Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee A set of copper(II) complexes of glycine and methylated glycine derivatives, Cu(aa)2, consisting of C-dimethylglycine, l-alanine, N-dimethylglycine and sarcosine, was investigated for their DNA binding and nucleolytic properties by means of EPR and visible spectroscopy, and electrophoresis. They bind weakly to DNA with apparent binding constants in the range 1.8–2.9 × 103 M−1 with very similar orientation. No DNA cleavage is observed in the absence of exogenous agents. Copper(II) complexes of N-methylated derivatives bind to DNA more stereo-specifically and less strongly, and their oxidative DNA cleavage is less efficient than those of the corresponding C-methylated derivatives in the presence of hydrogen peroxide (H2O2) alone, or sodium ascorbate (NaHA) alone or tandem H2O2–NaHA. The oxidative DNA cleavage mechanism in the three systems involves a common copper(I) species. Neocuproine can inhibit DNA cleavage by these complexes. Pergamon Press 2009-07-06 Article PeerReviewed Seng, Hoi Ling and Tan, Kong Wai and Maah, Mohd Jamil and Tan, Wee Tee and Hamada, Hirokazu and Chikira, Makoto and Ng, Chew Hee (2009) Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property. Polyhedron, 28 (11). pp. 2219-2227. ISSN 0277-5387; ESSN: 1873-3719 10.1016/j.poly.2009.03.022 |
| spellingShingle | Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property |
| title | Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property |
| title_full | Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property |
| title_fullStr | Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property |
| title_full_unstemmed | Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property |
| title_short | Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property |
| title_sort | copper ii complexes of methylated glycine derivatives effect of methyl substituent on their dna binding and nucleolytic property |
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