Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid
Crystal structure analysis of the zinc complex establishes it as a distorted octahedral complex, bis(3-methylpicolinato-κ2 N,O)2(1,10-phenanthroline-κ2 N,N)-zinc(II) pentahydrate, [Zn(3-Me-pic)2(phen)]·5H2O. The trans-configuration of carbonyl oxygen atoms of the carboxylate moieties and orientation...
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| Format: | Article |
| Language: | English |
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Springer
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13835/1/Crystal%20structure%2C%20DNA%20binding%20studies%2C%20nucleolytic%20property%20and%20topoisomerase%20I%20inhibition%20of%20zinc%20complex%20with%201%2C10-phenanthroline%20and%203%20methyl-picolinic%20acid.pdf |
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| author | Seng, Hoi Ling Von, Sze Tin Tan, Kong Wai Maah, Mohd Jamil Ng, Seik Weng Raja Abdul Rahman, Raja Noor Zaliha Caracelli, Ignez Ng, Chew Hee |
| author_facet | Seng, Hoi Ling Von, Sze Tin Tan, Kong Wai Maah, Mohd Jamil Ng, Seik Weng Raja Abdul Rahman, Raja Noor Zaliha Caracelli, Ignez Ng, Chew Hee |
| author_sort | Seng, Hoi Ling |
| collection | UPM |
| description | Crystal structure analysis of the zinc complex establishes it as a distorted octahedral complex, bis(3-methylpicolinato-κ2 N,O)2(1,10-phenanthroline-κ2 N,N)-zinc(II) pentahydrate, [Zn(3-Me-pic)2(phen)]·5H2O. The trans-configuration of carbonyl oxygen atoms of the carboxylate moieties and orientation of the two planar picolinate ligands above and before the phen ligand plane seems to confer DNA sequence recognition to the complex. It cannot cleave DNA under hydrolytic condition but can slightly be activated by hydrogen peroxide or sodium ascorbate. Circular Dichroism and Fluorescence spectroscopic analysis of its interaction with various duplex polynucleotides reveals its binding mode as mainly intercalation. It shows distinct DNA sequence binding selectivity and the order of decreasing selectivity is ATAT > AATT > CGCG. Docking studies lead to the same conclusion on this sequence selectivity. It binds strongly with G-quadruplex with human tolemeric sequence 5′-AG3(T2AG3)3-3′, can inhibit topoisomerase I efficiently and is cytotoxic against MCF-7 cell line. |
| first_indexed | 2024-03-06T07:29:32Z |
| format | Article |
| id | upm.eprints-13835 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:29:32Z |
| publishDate | 2010 |
| publisher | Springer |
| record_format | dspace |
| spelling | upm.eprints-138352016-09-26T08:42:48Z http://psasir.upm.edu.my/id/eprint/13835/ Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid Seng, Hoi Ling Von, Sze Tin Tan, Kong Wai Maah, Mohd Jamil Ng, Seik Weng Raja Abdul Rahman, Raja Noor Zaliha Caracelli, Ignez Ng, Chew Hee Crystal structure analysis of the zinc complex establishes it as a distorted octahedral complex, bis(3-methylpicolinato-κ2 N,O)2(1,10-phenanthroline-κ2 N,N)-zinc(II) pentahydrate, [Zn(3-Me-pic)2(phen)]·5H2O. The trans-configuration of carbonyl oxygen atoms of the carboxylate moieties and orientation of the two planar picolinate ligands above and before the phen ligand plane seems to confer DNA sequence recognition to the complex. It cannot cleave DNA under hydrolytic condition but can slightly be activated by hydrogen peroxide or sodium ascorbate. Circular Dichroism and Fluorescence spectroscopic analysis of its interaction with various duplex polynucleotides reveals its binding mode as mainly intercalation. It shows distinct DNA sequence binding selectivity and the order of decreasing selectivity is ATAT > AATT > CGCG. Docking studies lead to the same conclusion on this sequence selectivity. It binds strongly with G-quadruplex with human tolemeric sequence 5′-AG3(T2AG3)3-3′, can inhibit topoisomerase I efficiently and is cytotoxic against MCF-7 cell line. Springer 2010-02-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13835/1/Crystal%20structure%2C%20DNA%20binding%20studies%2C%20nucleolytic%20property%20and%20topoisomerase%20I%20inhibition%20of%20zinc%20complex%20with%201%2C10-phenanthroline%20and%203%20methyl-picolinic%20acid.pdf Seng, Hoi Ling and Von, Sze Tin and Tan, Kong Wai and Maah, Mohd Jamil and Ng, Seik Weng and Raja Abdul Rahman, Raja Noor Zaliha and Caracelli, Ignez and Ng, Chew Hee (2010) Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid. BioMetals, 23 (1). pp. 99-118. ISSN 0966-0844; ESSN: 1572-8773 http://link.springer.com/article/10.1007/s10534-009-9271-y?view=classic 10.1007/s10534-009-9271-y |
| spellingShingle | Seng, Hoi Ling Von, Sze Tin Tan, Kong Wai Maah, Mohd Jamil Ng, Seik Weng Raja Abdul Rahman, Raja Noor Zaliha Caracelli, Ignez Ng, Chew Hee Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid |
| title | Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid |
| title_full | Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid |
| title_fullStr | Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid |
| title_full_unstemmed | Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid |
| title_short | Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3 methyl-picolinic acid |
| title_sort | crystal structure dna binding studies nucleolytic property and topoisomerase i inhibition of zinc complex with 1 10 phenanthroline and 3 methyl picolinic acid |
| url | http://psasir.upm.edu.my/id/eprint/13835/1/Crystal%20structure%2C%20DNA%20binding%20studies%2C%20nucleolytic%20property%20and%20topoisomerase%20I%20inhibition%20of%20zinc%20complex%20with%201%2C10-phenanthroline%20and%203%20methyl-picolinic%20acid.pdf |
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