Determination of mitragynine bound opioid receptors
Mitragyna Speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance...
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| Format: | Article |
| Language: | English |
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American-Eurasian Network for Scientific Information
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13954/1/Determination%20of%20mitragynine%20bound%20opioid%20receptors.pdf |
| _version_ | 1825945335650844672 |
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| author | Baharuldin, Mohamad Taufik Hidayat Apryani, Evhy Mohamad, Nabishah Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adzhar, Muhammad Farhan |
| author_facet | Baharuldin, Mohamad Taufik Hidayat Apryani, Evhy Mohamad, Nabishah Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adzhar, Muhammad Farhan |
| author_sort | Baharuldin, Mohamad Taufik Hidayat |
| collection | UPM |
| description | Mitragyna Speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance to hard work. This study is designed to examine the binding affinity and selectivity of mitragynine towards opioid receptors namely µ-, δ-, and κ-receptors and the density of those opioid receptors in brain tissues, spinal cord, duodenum, ileum and vas deferens. Our results suggest that mitragynine has a high affinity to the 9-opioid receptors and brain has the highest density of opioid receptors. |
| first_indexed | 2024-03-06T07:29:54Z |
| format | Article |
| id | upm.eprints-13954 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:29:54Z |
| publishDate | 2010 |
| publisher | American-Eurasian Network for Scientific Information |
| record_format | dspace |
| spelling | upm.eprints-139542017-11-08T03:06:21Z http://psasir.upm.edu.my/id/eprint/13954/ Determination of mitragynine bound opioid receptors Baharuldin, Mohamad Taufik Hidayat Apryani, Evhy Mohamad, Nabishah Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adzhar, Muhammad Farhan Mitragyna Speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance to hard work. This study is designed to examine the binding affinity and selectivity of mitragynine towards opioid receptors namely µ-, δ-, and κ-receptors and the density of those opioid receptors in brain tissues, spinal cord, duodenum, ileum and vas deferens. Our results suggest that mitragynine has a high affinity to the 9-opioid receptors and brain has the highest density of opioid receptors. American-Eurasian Network for Scientific Information 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13954/1/Determination%20of%20mitragynine%20bound%20opioid%20receptors.pdf Baharuldin, Mohamad Taufik Hidayat and Apryani, Evhy and Mohamad, Nabishah and Mohd Moklas, Mohamad Aris and Fakurazi, Sharida and Adzhar, Muhammad Farhan (2010) Determination of mitragynine bound opioid receptors. Advances in Medical and Dental Sciences, 3 (3). pp. 65-70. ISSN 1995-0764; ESSN: 1998-1082 http://arnmsmb.com/old/amds_sept-dec_2009.html |
| spellingShingle | Baharuldin, Mohamad Taufik Hidayat Apryani, Evhy Mohamad, Nabishah Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adzhar, Muhammad Farhan Determination of mitragynine bound opioid receptors |
| title | Determination of mitragynine bound opioid receptors |
| title_full | Determination of mitragynine bound opioid receptors |
| title_fullStr | Determination of mitragynine bound opioid receptors |
| title_full_unstemmed | Determination of mitragynine bound opioid receptors |
| title_short | Determination of mitragynine bound opioid receptors |
| title_sort | determination of mitragynine bound opioid receptors |
| url | http://psasir.upm.edu.my/id/eprint/13954/1/Determination%20of%20mitragynine%20bound%20opioid%20receptors.pdf |
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