Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats.
Brown rice (BR) or unmilled rice is the whole grain of rice, from which the germ and outer layers containing the bran have not been removed. Brown rice seeds are rich in more nutritional components, such as dietary fibers, vitamins B and E, gamma (γ)-oryzanol and γ-amino butyric acid (GABA) than the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
WFL Publisher
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14258/1/Effect%20of%20hypocholesterolemic%20properties%20of%20brown%20rice%20varieties%20containing%20different%20gamma%20aminobutyric%20acid.pdf |
| _version_ | 1796968608254918656 |
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| author | Roohinejad, Shahin Omidizadeh, Alireza Mirhosseini, Hamed Rasti, Babak Saari, Nazamid Mustafa, Shuhaimi Mohd Yusof , Rokiah Meor Hussin, Anis Shobirin Hamid, Azizah Abd Manap, Mohd Yazid |
| author_facet | Roohinejad, Shahin Omidizadeh, Alireza Mirhosseini, Hamed Rasti, Babak Saari, Nazamid Mustafa, Shuhaimi Mohd Yusof , Rokiah Meor Hussin, Anis Shobirin Hamid, Azizah Abd Manap, Mohd Yazid |
| author_sort | Roohinejad, Shahin |
| collection | UPM |
| description | Brown rice (BR) or unmilled rice is the whole grain of rice, from which the germ and outer layers containing the bran have not been removed. Brown rice seeds are rich in more nutritional components, such as dietary fibers, vitamins B and E, gamma (γ)-oryzanol and γ-amino butyric acid (GABA) than the ordinary milled rice grains. GABA or 4-aminobutyrate is a well known non-protein-based amino acid that is one of the major inhibitory neurotransmitters in the sympathetic nervous system. In the present study, the influence of brown rice varieties containing different GABA levels on blood cholesterol in Sprague-Dawley male rats was investigated. Quantitative analysis of GABA, Gamma oryzanol, dietary fiber, protein and fat was carried out using appropriate method. Hypercholesterolemia and elevation of LDL-cholesterol was successfully ameliorated by most of the brown rice diets (p < 0.05). A significant negative correlation (p < 0.05) between serum TC level and γ-oryzanol content of diets was observed. Moreover, a significant negative correlation (p < 0.05) between serum LDL-C level and dietary fiber content of diets was observed. In contrast, there was no correlation between GABA content and TC, LDL-C, HDL-C and glucose levels. Although no correlation was found between GABA content and lipid profile suppression, this study suggests that the changes of blood cholesterol can be modulated by using brown rice varieties instead of polished rice in human diet. Even though GABA not played a role for prediction of lipid profile changes, this study was capable to show the hypercholesterolemic effect of brown rice verities. |
| first_indexed | 2024-03-06T07:30:50Z |
| format | Article |
| id | upm.eprints-14258 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:30:50Z |
| publishDate | 2009 |
| publisher | WFL Publisher |
| record_format | dspace |
| spelling | upm.eprints-142582015-11-02T23:50:23Z http://psasir.upm.edu.my/id/eprint/14258/ Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. Roohinejad, Shahin Omidizadeh, Alireza Mirhosseini, Hamed Rasti, Babak Saari, Nazamid Mustafa, Shuhaimi Mohd Yusof , Rokiah Meor Hussin, Anis Shobirin Hamid, Azizah Abd Manap, Mohd Yazid Brown rice (BR) or unmilled rice is the whole grain of rice, from which the germ and outer layers containing the bran have not been removed. Brown rice seeds are rich in more nutritional components, such as dietary fibers, vitamins B and E, gamma (γ)-oryzanol and γ-amino butyric acid (GABA) than the ordinary milled rice grains. GABA or 4-aminobutyrate is a well known non-protein-based amino acid that is one of the major inhibitory neurotransmitters in the sympathetic nervous system. In the present study, the influence of brown rice varieties containing different GABA levels on blood cholesterol in Sprague-Dawley male rats was investigated. Quantitative analysis of GABA, Gamma oryzanol, dietary fiber, protein and fat was carried out using appropriate method. Hypercholesterolemia and elevation of LDL-cholesterol was successfully ameliorated by most of the brown rice diets (p < 0.05). A significant negative correlation (p < 0.05) between serum TC level and γ-oryzanol content of diets was observed. Moreover, a significant negative correlation (p < 0.05) between serum LDL-C level and dietary fiber content of diets was observed. In contrast, there was no correlation between GABA content and TC, LDL-C, HDL-C and glucose levels. Although no correlation was found between GABA content and lipid profile suppression, this study suggests that the changes of blood cholesterol can be modulated by using brown rice varieties instead of polished rice in human diet. Even though GABA not played a role for prediction of lipid profile changes, this study was capable to show the hypercholesterolemic effect of brown rice verities. WFL Publisher 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14258/1/Effect%20of%20hypocholesterolemic%20properties%20of%20brown%20rice%20varieties%20containing%20different%20gamma%20aminobutyric%20acid.pdf Roohinejad, Shahin and Omidizadeh, Alireza and Mirhosseini, Hamed and Rasti, Babak and Saari, Nazamid and Mustafa, Shuhaimi and Mohd Yusof , Rokiah and Meor Hussin, Anis Shobirin and Hamid, Azizah and Abd Manap, Mohd Yazid (2009) Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. Journal of Food, Agriculture and Environment, 7 (3 & 4). pp. 197-203. ISSN 1459-0255 http://world-food.net English |
| spellingShingle | Roohinejad, Shahin Omidizadeh, Alireza Mirhosseini, Hamed Rasti, Babak Saari, Nazamid Mustafa, Shuhaimi Mohd Yusof , Rokiah Meor Hussin, Anis Shobirin Hamid, Azizah Abd Manap, Mohd Yazid Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. |
| title | Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. |
| title_full | Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. |
| title_fullStr | Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. |
| title_full_unstemmed | Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. |
| title_short | Effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid (GABA) levels on Sprague-Dawley male rats. |
| title_sort | effect of hypocholesterolemic properties of brown rice varieties containing different gamma aminobutyric acid gaba levels on sprague dawley male rats |
| url | http://psasir.upm.edu.my/id/eprint/14258/1/Effect%20of%20hypocholesterolemic%20properties%20of%20brown%20rice%20varieties%20containing%20different%20gamma%20aminobutyric%20acid.pdf |
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