Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract.
The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
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Springer Verlag
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14613/1/Evaluation%20of%20the%20anti.pdf |
| _version_ | 1825945461660319744 |
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| author | Yam, Mun Fee Ang, Lee Fung Basir, Rusliza Salman, Muhammad Ibrahim Ameer, Omar Ziad Asmawil, Mohd Zaini |
| author_facet | Yam, Mun Fee Ang, Lee Fung Basir, Rusliza Salman, Muhammad Ibrahim Ameer, Omar Ziad Asmawil, Mohd Zaini |
| author_sort | Yam, Mun Fee |
| collection | UPM |
| description | The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD 50 of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity. |
| first_indexed | 2024-03-06T07:31:53Z |
| format | Article |
| id | upm.eprints-14613 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:31:53Z |
| publishDate | 2009 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | upm.eprints-146132015-11-04T02:52:14Z http://psasir.upm.edu.my/id/eprint/14613/ Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. Yam, Mun Fee Ang, Lee Fung Basir, Rusliza Salman, Muhammad Ibrahim Ameer, Omar Ziad Asmawil, Mohd Zaini The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD 50 of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity. Springer Verlag 2009-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14613/1/Evaluation%20of%20the%20anti.pdf Yam, Mun Fee and Ang, Lee Fung and Basir, Rusliza and Salman, Muhammad Ibrahim and Ameer, Omar Ziad and Asmawil, Mohd Zaini (2009) Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. Inflammopharmacology, 17 (1). pp. 50-54. ISSN 0925-4692; ESSN: 1568-5608 10.1007/s10787-008-8038-3 English |
| spellingShingle | Yam, Mun Fee Ang, Lee Fung Basir, Rusliza Salman, Muhammad Ibrahim Ameer, Omar Ziad Asmawil, Mohd Zaini Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| title | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| title_full | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| title_fullStr | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| title_full_unstemmed | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| title_short | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| title_sort | evaluation of the anti pyretic potential of orthosiphon stamineus benth standardized extract |
| url | http://psasir.upm.edu.my/id/eprint/14613/1/Evaluation%20of%20the%20anti.pdf |
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